Entity Details

Name PTPN3
ID P26045
Role phosphatase
Enzymatic Domains
FERM 29-312
PROSITE-ProRule
PDZ 510-582
PROSITE-ProRule
Tyrosine-protein phosphatase 646-901
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN3ESR1Tyr537CKNVVPLyDLLLEMLdephosphorylation
up-regulates activity		26079946SIGNOR-277127
PTPN3GHRTyr534NFLMDNAyFCEADAKdephosphorylation
down-regulates activity		12907755SIGNOR-248459
PTPN3VCPTyr796GGTGGSVyTEDNDDDdephosphorylation
down-regulates activity		10364224SIGNOR-248460
PTPN3VCPTyr805EDNDDDLyGdephosphorylation
down-regulates activity		10364224SIGNOR-248461
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN3dephosphorylation
down-regulates
⊣
ESR1
PTyr537		dephosphorylation
down-regulates
⊣		ESR126079946SIGNOR-277127
PTPN3dephosphorylation
down-regulates
⊣
GHR
PTyr534		dephosphorylation
up-regulates
→		GHR12907755SIGNOR-248459
PTPN3dephosphorylation
down-regulates
⊣
VCP
PTyr796		dephosphorylation
up-regulates
→		VCP10364224SIGNOR-248460
PTPN3dephosphorylation
down-regulates
⊣
VCP
PTyr805		dephosphorylation
up-regulates
→		VCP10364224SIGNOR-248461
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN3dephosphorylation
→
up-regulates activity 		ESR1SIGNOR-277127
PTPN3dephosphorylation
→
down-regulates activity 		GHRSIGNOR-248459
PTPN3dephosphorylation
→
down-regulates activity 		VCPSIGNOR-248460
PTPN3dephosphorylation
→
down-regulates activity 		VCPSIGNOR-248461