| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | ZFP36 | – | phosphorylation down-regulates activity | 25815583 | SIGNOR-253596 | |
| MAPKAPK2 | ZFP36 | Ser186 | PVLRQSIsFSGLPSG | phosphorylation down-regulates activity | 14688255 | SIGNOR-250152 |
| MAPKAPK2 | ZFP36 | Ser184 | HPPVLRQsISFSGLP | phosphorylation down-regulates activity | 14688255 | SIGNOR-250153 |
| MAPKAPK2 | ZFP36 | Ser60 | RLPGRSTsLVEGRSC | phosphorylation down-regulates activity | 14688255 | SIGNOR-250155 |
| MAPKAPK2 | ZFP36 | Ser66 | TSLVEGRsCGWVPPP | phosphorylation down-regulates activity | 14688255 | SIGNOR-250154 |
| MAPKAPK2 | ZFP36 | Ser113 | TELCRTFsESGRCRY | phosphorylation down-regulates activity | 14688255 | SIGNOR-250156 |
| MAPK1 | ZFP36 | Ser228 | PPGDLPLsPSAFSAA | phosphorylation unknown | 7768935 | SIGNOR-249456 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer186 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250152 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer184 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250153 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer60 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250155 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer66 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250154 |
| MAPKAPK2 | phosphorylation up-regulates → | ZFP36 PSer113 | phosphorylation down-regulates ⊣ | ZFP36 | 14688255 | SIGNOR-250156 |
| MAPK1 | phosphorylation up-regulates → | ZFP36 PSer228 | phosphorylation down-regulates ⊣ | ZFP36 | 7768935 | SIGNOR-249456 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-253596 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250152 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250153 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250155 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250154 |
| MAPKAPK2 | phosphorylation → down-regulates activity | ZFP36 | SIGNOR-250156 |
| MAPK1 | phosphorylation → unknown | ZFP36 | SIGNOR-249456 |
