Entity Details

Name	ZFP36
ID	P26651
Role	substrate
Enzymatic Domains
View in

Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPKAPK2	ZFP36	Ser184	HPPVLRQsISFSGLP	phosphorylation down-regulates activity	14688255	SIGNOR-250153
MAPKAPK2	ZFP36	Ser60 View in OncoXplorer	RLPGRSTsLVEGRSC	phosphorylation down-regulates activity	14688255	SIGNOR-250155
MAPKAPK2	ZFP36	Ser113 View in OncoXplorer	TELCRTFsESGRCRY	phosphorylation down-regulates activity	14688255	SIGNOR-250156
MAPKAPK2	ZFP36	Ser66	TSLVEGRsCGWVPPP	phosphorylation down-regulates activity	14688255	SIGNOR-250154
MAPK1	ZFP36	Ser228	PPGDLPLsPSAFSAA	phosphorylation unknown	7768935	SIGNOR-249456
MAPK14	ZFP36	–		phosphorylation down-regulates activity	25815583	SIGNOR-253596
MAPKAPK2	ZFP36	Ser186 View in OncoXplorer	PVLRQSIsFSGLPSG	phosphorylation down-regulates activity	14688255	SIGNOR-250152

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPKAPK2	phosphorylation up-regulates →	ZFP36 PSer184	phosphorylation down-regulates ⊣	ZFP36	14688255	SIGNOR-250153
MAPKAPK2	phosphorylation up-regulates →	ZFP36 PSer60	phosphorylation down-regulates ⊣	ZFP36	14688255	SIGNOR-250155
MAPKAPK2	phosphorylation up-regulates →	ZFP36 PSer113	phosphorylation down-regulates ⊣	ZFP36	14688255	SIGNOR-250156
MAPKAPK2	phosphorylation up-regulates →	ZFP36 PSer66	phosphorylation down-regulates ⊣	ZFP36	14688255	SIGNOR-250154
MAPK1	phosphorylation up-regulates →	ZFP36 PSer228	phosphorylation down-regulates ⊣	ZFP36	7768935	SIGNOR-249456
MAPKAPK2	phosphorylation up-regulates →	ZFP36 PSer186	phosphorylation down-regulates ⊣	ZFP36	14688255	SIGNOR-250152

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPKAPK2	phosphorylation → down-regulates activity	ZFP36	SIGNOR-250153
MAPKAPK2	phosphorylation → down-regulates activity	ZFP36	SIGNOR-250155
MAPKAPK2	phosphorylation → down-regulates activity	ZFP36	SIGNOR-250156
MAPKAPK2	phosphorylation → down-regulates activity	ZFP36	SIGNOR-250154
MAPK1	phosphorylation → unknown	ZFP36	SIGNOR-249456
MAPK14	phosphorylation → down-regulates activity	ZFP36	SIGNOR-253596
MAPKAPK2	phosphorylation → down-regulates activity	ZFP36	SIGNOR-250152