| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | DCK | Ser74 | EFEELTMsQKNGGNV | phosphorylation up-regulates activity | 27879648 | SIGNOR-275798 |
| PPP2CA | DCK | Ser74 | EFEELTMsQKNGGNV | dephosphorylation down-regulates activity | 24462681 | SIGNOR-275803 |
| ATM | DCK | Ser74 | EFEELTMsQKNGGNV | phosphorylation up-regulates activity | 22850745 | SIGNOR-278221 |
| ATR | DCK | Ser74 | EFEELTMsQKNGGNV | phosphorylation up-regulates activity | 26620371 | SIGNOR-279494 |
| PP2Ca_R1A_Bd | DCK | Ser74 | EFEELTMsQKNGGNV | dephosphorylation down-regulates activity | 24462681 | SIGNOR-275802 |
| CSNK1D | DCK | Ser74 | EFEELTMsQKNGGNV | phosphorylation up-regulates activity | 20637175 | SIGNOR-275799 |
| PP2CA_R1A_R2A | DCK | Ser74 | EFEELTMsQKNGGNV | dephosphorylation down-regulates activity | 24462681 | SIGNOR-275804 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | DCK PSer74 | phosphorylation up-regulates → | DCK | 27879648 | SIGNOR-275798 |
| PPP2CA | dephosphorylation down-regulates ⊣ | DCK PSer74 | dephosphorylation up-regulates → | DCK | 24462681 | SIGNOR-275803 |
| ATM | phosphorylation up-regulates → | DCK PSer74 | phosphorylation up-regulates → | DCK | 22850745 | SIGNOR-278221 |
| ATR | phosphorylation up-regulates → | DCK PSer74 | phosphorylation up-regulates → | DCK | 26620371 | SIGNOR-279494 |
| PP2Ca_R1A_Bd | dephosphorylation down-regulates ⊣ | DCK PSer74 | dephosphorylation up-regulates → | DCK | 24462681 | SIGNOR-275802 |
| CSNK1D | phosphorylation up-regulates → | DCK PSer74 | phosphorylation up-regulates → | DCK | 20637175 | SIGNOR-275799 |
| PP2CA_R1A_R2A | dephosphorylation down-regulates ⊣ | DCK PSer74 | dephosphorylation up-regulates → | DCK | 24462681 | SIGNOR-275804 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates activity | DCK | SIGNOR-275798 |
| PPP2CA | dephosphorylation → down-regulates activity | DCK | SIGNOR-275803 |
| ATM | phosphorylation → up-regulates activity | DCK | SIGNOR-278221 |
| ATR | phosphorylation → up-regulates activity | DCK | SIGNOR-279494 |
| PP2Ca_R1A_Bd | dephosphorylation → down-regulates activity | DCK | SIGNOR-275802 |
| CSNK1D | phosphorylation → up-regulates activity | DCK | SIGNOR-275799 |
| PP2CA_R1A_R2A | dephosphorylation → down-regulates activity | DCK | SIGNOR-275804 |
