| Name | CAD |
| ID | P27708 |
| Role | substrate |
| Enzymatic Domains |
Glutamine amidotransferase type-1 177-363 PROSITE-ProRule
ATP-grasp 1 519-711 PROSITE-ProRule
ATP-grasp 2 1052-1243 PROSITE-ProRule
MGS-like 1308-1462 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | CAD | Ser1406 | GAGGRRLsSFVTKGY | phosphorylation down-regulates activity | 17485345 | SIGNOR-267442 |
| PRKACA | CAD | Ser1406 | GAGGRRLsSFVTKGY | phosphorylation down-regulates activity | 11986331 | SIGNOR-250344 |
| MAPK3 | CAD | Thr456 | KVYFLPItPHYVTQV | phosphorylation up-regulates | 15890648 | SIGNOR-137179 |
| PP1 | CAD | Ser1406 | GAGGRRLsSFVTKGY | dephosphorylation down-regulates activity | 4092695 | SIGNOR-264653 |
| PRKACA | CAD | Ser1859 | PPRIHRAsDPGLPAE | phosphorylation unknown | 11986331 | SIGNOR-250343 |
| ERK1/2 | CAD | Thr456 | KVYFLPItPHYVTQV | phosphorylation up-regulates activity | 17485345 | SIGNOR-267441 |
| MAPK1 | CAD | Thr456 | KVYFLPItPHYVTQV | phosphorylation up-regulates | 15890648 | SIGNOR-137171 |
| RPS6K | CAD | Ser1859 | PPRIHRAsDPGLPAE | phosphorylation up-regulates activity | 23429703 | SIGNOR-267197 |
| Gbeta | CAD | – | phosphorylation up-regulates | 15890648 | SIGNOR-269998 | |
| RPS6KB1 | CAD | Ser1859 | PPRIHRAsDPGLPAE | phosphorylation up-regulates | 23429703 | SIGNOR-201117 |
| PRKACA | CAD | Ser1406 | GAGGRRLsSFVTKGY | phosphorylation down-regulates | 17206380 | SIGNOR-151816 |
| PPP1CA | CAD | Ser1406 | CSGAGGRrLSSFVTK | dephosphorylation down-regulates activity | 4092695 | SIGNOR-263741 |
| RPS6KB1 | CAD | Ser1859 | PPRIHRAsDPGLPAE | phosphorylation up-regulates activity | 23429703 | SIGNOR-267443 |
| CAD | CAD | Thr1037 | QQCRVLGtSPEAIDS | phosphorylation up-regulates activity | 11986331 | SIGNOR-250610 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | CAD PSer1406 | phosphorylation down-regulates ⊣ | CAD | 17485345 | SIGNOR-267442 |
| PRKACA | phosphorylation up-regulates → | CAD PSer1406 | phosphorylation down-regulates ⊣ | CAD | 11986331 | SIGNOR-250344 |
| MAPK3 | phosphorylation up-regulates → | CAD PThr456 | phosphorylation up-regulates → | CAD | 15890648 | SIGNOR-137179 |
| PP1 | dephosphorylation down-regulates ⊣ | CAD PSer1406 | dephosphorylation up-regulates → | CAD | 4092695 | SIGNOR-264653 |
| PRKACA | phosphorylation up-regulates → | CAD PSer1859 | phosphorylation down-regulates ⊣ | CAD | 11986331 | SIGNOR-250343 |
| ERK1/2 | phosphorylation up-regulates → | CAD PThr456 | phosphorylation up-regulates → | CAD | 17485345 | SIGNOR-267441 |
| MAPK1 | phosphorylation up-regulates → | CAD PThr456 | phosphorylation up-regulates → | CAD | 15890648 | SIGNOR-137171 |
| RPS6K | phosphorylation up-regulates → | CAD PSer1859 | phosphorylation up-regulates → | CAD | 23429703 | SIGNOR-267197 |
| RPS6KB1 | phosphorylation up-regulates → | CAD PSer1859 | phosphorylation up-regulates → | CAD | 23429703 | SIGNOR-201117 |
| PRKACA | phosphorylation up-regulates → | CAD PSer1406 | phosphorylation down-regulates ⊣ | CAD | 17206380 | SIGNOR-151816 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CAD PSer1406 | dephosphorylation up-regulates → | CAD | 4092695 | SIGNOR-263741 |
| RPS6KB1 | phosphorylation up-regulates → | CAD PSer1859 | phosphorylation up-regulates → | CAD | 23429703 | SIGNOR-267443 |
| CAD | phosphorylation up-regulates → | CAD PThr1037 | phosphorylation up-regulates → | CAD | 11986331 | SIGNOR-250610 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | CAD | SIGNOR-267442 |
| PRKACA | phosphorylation → down-regulates activity | CAD | SIGNOR-250344 |
| MAPK3 | phosphorylation → up-regulates | CAD | SIGNOR-137179 |
| PP1 | dephosphorylation → down-regulates activity | CAD | SIGNOR-264653 |
| PRKACA | phosphorylation → unknown | CAD | SIGNOR-250343 |
| ERK1/2 | phosphorylation → up-regulates activity | CAD | SIGNOR-267441 |
| MAPK1 | phosphorylation → up-regulates | CAD | SIGNOR-137171 |
| RPS6K | phosphorylation → up-regulates activity | CAD | SIGNOR-267197 |
| Gbeta | phosphorylation → up-regulates | CAD | SIGNOR-269998 |
| RPS6KB1 | phosphorylation → up-regulates | CAD | SIGNOR-201117 |
| PRKACA | phosphorylation down-regulates | CAD | SIGNOR-151816 |
| PPP1CA | dephosphorylation → down-regulates activity | CAD | SIGNOR-263741 |
| RPS6KB1 | phosphorylation → up-regulates activity | CAD | SIGNOR-267443 |
| CAD | phosphorylation → up-regulates activity | CAD | SIGNOR-250610 |