| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | CAD | Ser1406 | GAGGRRLsSFVTKGY | phosphorylation down-regulates activity | 17485345 | SIGNOR-267442 |
| PPP1CA | CAD | Ser1406 | CSGAGGRrLSSFVTK | dephosphorylation down-regulates activity | 4092695 | SIGNOR-263741 |
| PRKACA | CAD | Ser1406 | GAGGRRLsSFVTKGY | phosphorylation down-regulates activity | 11986331 | SIGNOR-250344 |
| PRKACA | CAD | Ser1406 | GAGGRRLsSFVTKGY | phosphorylation down-regulates | 17206380 | SIGNOR-151816 |
| PP1 | CAD | Ser1406 | GAGGRRLsSFVTKGY | dephosphorylation down-regulates activity | 4092695 | SIGNOR-264653 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | CAD PSer1406 | phosphorylation down-regulates ⊣ | CAD | 17485345 | SIGNOR-267442 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CAD PSer1406 | dephosphorylation up-regulates → | CAD | 4092695 | SIGNOR-263741 |
| PRKACA | phosphorylation up-regulates → | CAD PSer1406 | phosphorylation down-regulates ⊣ | CAD | 11986331 | SIGNOR-250344 |
| PRKACA | phosphorylation up-regulates → | CAD PSer1406 | phosphorylation down-regulates ⊣ | CAD | 17206380 | SIGNOR-151816 |
| PP1 | dephosphorylation down-regulates ⊣ | CAD PSer1406 | dephosphorylation up-regulates → | CAD | 4092695 | SIGNOR-264653 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | CAD | SIGNOR-267442 |
| PPP1CA | dephosphorylation → down-regulates activity | CAD | SIGNOR-263741 |
| PRKACA | phosphorylation → down-regulates activity | CAD | SIGNOR-250344 |
| PRKACA | phosphorylation down-regulates | CAD | SIGNOR-151816 |
| PP1 | dephosphorylation → down-regulates activity | CAD | SIGNOR-264653 |
