| Name | PDE4A |
| ID | P27815 |
| Role | substrate |
| Enzymatic Domains |
PDEase 357-686 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | PDE4A | Ser89 | TRMSWPSsFHGTGTG | phosphorylation up-regulates activity | 12023945 | SIGNOR-273937 |
| PKA | PDE4A | Ser145 | ATSQRREsFLYRSDS | phosphorylation up-regulates activity | 12023945 | SIGNOR-275985 |
| MAPKAPK2 | PDE4A | Ser152 | SFLYRSDsDYDMSPK | phosphorylation down-regulates activity | 21323643 | SIGNOR-263078 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | PDE4A PSer89 | phosphorylation up-regulates → | PDE4A | 12023945 | SIGNOR-273937 |
| PKA | phosphorylation up-regulates → | PDE4A PSer145 | phosphorylation up-regulates → | PDE4A | 12023945 | SIGNOR-275985 |
| MAPKAPK2 | phosphorylation up-regulates → | PDE4A PSer152 | phosphorylation down-regulates ⊣ | PDE4A | 21323643 | SIGNOR-263078 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → up-regulates activity | PDE4A | SIGNOR-273937 |
| PKA | phosphorylation → up-regulates activity | PDE4A | SIGNOR-275985 |
| MAPKAPK2 | phosphorylation → down-regulates activity | PDE4A | SIGNOR-263078 |