| Name | MAPK1 |
| ID | P28482 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 25-313 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 1712480 | SIGNOR-249415 |
| MAP2K2 | MAPK1 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258996 | |
| PP1 | MAPK1 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-264664 | |
| AKT1 | MAPK1 | – | phosphorylation up-regulates activity | 20693286 | SIGNOR-279136 | |
| PRKCH | MAPK1 | – | phosphorylation up-regulates activity | 28939105 | SIGNOR-261910 | |
| DUSP5 | MAPK1 | – | dephosphorylation down-regulates | 15713638 | SIGNOR-134049 | |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates | 16456541 | SIGNOR-143052 |
| PTPN7 | MAPK1 | – | dephosphorylation down-regulates | 10415025 | SIGNOR-69448 | |
| DUSP1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248465 |
| PBK | MAPK1 | – | phosphorylation up-regulates activity | 17631144 | SIGNOR-278417 | |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 12840032 | SIGNOR-103159 |
| PTPRE | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 12754301 | SIGNOR-248449 |
| PPP1CA | MAPK1 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103152 | |
| DUSP3 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10224087 | SIGNOR-248536 |
| MAPK1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 1712480 | SIGNOR-249414 |
| PTPRJ | MAPK1 | Tyr205 | IMLNSKGyTKSIDIW | dephosphorylation down-regulates activity | 19494114 | SIGNOR-101276 |
| PTPN7 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 16226275 | SIGNOR-248483 |
| PTPRJ | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 19494114 | SIGNOR-248708 |
| MEK1/2 | MAPK1 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258990 | |
| DUSP1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248464 |
| PTPRJ | MAPK1 | – | dephosphorylation down-regulates | 12771128 | SIGNOR-101279 | |
| DUSP5 | MAPK1 | – | dephosphorylation down-regulates | 10224087 | SIGNOR-67355 | |
| PTPN7 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10702794 | SIGNOR-248484 |
| MEK1/2 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 11971971 | SIGNOR-244788 |
| DUSP1 | MAPK1 | – | dephosphorylation down-regulates | 10617468 | SIGNOR-73614 | |
| MEK1/2 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 11971971 | SIGNOR-244792 |
| DUSP9 | MAPK1 | – | dephosphorylation down-regulates | 21908610 | SIGNOR-176586 | |
| DUSP4 | MAPK1 | – | dephosphorylation down-regulates | 8626452 | SIGNOR-40926 | |
| DUSP6 | MAPK1 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103146 | |
| MEK1/2 | MAPK1 | – | phosphorylation up-regulates activity | 12270934 | SIGNOR-244795 | |
| DUSP7 | MAPK1 | – | dephosphorylation down-regulates | 9788880 | SIGNOR-60871 | |
| DUSP4 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248718 |
| MAP2K1 | MAPK1 | – | phosphorylation up-regulates activity | 12270934 | SIGNOR-235940 | |
| DUSP4 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248717 |
| MAP2K2 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 11971971 | SIGNOR-86713 |
| DUSP6 | MAPK1 | – | dephosphorylation down-regulates activity | 20638106 | SIGNOR-277006 | |
| PTPRJ | MAPK1 | Tyr205 | IMLNSKGyTKSIDIW | dephosphorylation down-regulates | 19494114 | SIGNOR-161536 |
| PTPRB | MAPK1 | – | dephosphorylation down-regulates | 21454675 | SIGNOR-173000 | |
| PPP2CB | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7780739 | SIGNOR-248590 |
| PTPRE | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 12754301 | SIGNOR-248448 |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7780739 | SIGNOR-248625 |
| DUSP2 | MAPK1 | – | dephosphorylation down-regulates | 8626452 | SIGNOR-40915 | |
| PTPRR | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 11493009 | SIGNOR-248840 |
| MAP2K1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 11971971 | SIGNOR-236447 |
| MAP2K1 | MAPK1 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258993 | |
| MAP2K2 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 11971971 | SIGNOR-86709 |
| RIPK2 | MAPK1 | – | phosphorylation up-regulates activity | 10559258 | SIGNOR-279106 | |
| MAP2K1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 11971971 | SIGNOR-235937 |
| RET | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 16153436 | SIGNOR-140294 |
| PPP2CA | MAPK1 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166655 | |
| SGK1 | MAPK1 | Ser29 | GPRYTNLsYIGEGAY | phosphorylation up-regulates activity | 19447520 | SIGNOR-276223 |
| STK33 | MAPK1 | – | phosphorylation up-regulates activity | 30760631 | SIGNOR-279351 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 1712480 | SIGNOR-249415 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 16456541 | SIGNOR-143052 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248465 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 12840032 | SIGNOR-103159 |
| PTPRE | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 12754301 | SIGNOR-248449 |
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 10224087 | SIGNOR-248536 |
| MAPK1 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 1712480 | SIGNOR-249414 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr205 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-101276 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 16226275 | SIGNOR-248483 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-248708 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248464 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 10702794 | SIGNOR-248484 |
| MEK1/2 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-244788 |
| MEK1/2 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-244792 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248718 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248717 |
| MAP2K2 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-86713 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr205 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-161536 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7780739 | SIGNOR-248590 |
| PTPRE | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 12754301 | SIGNOR-248448 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7780739 | SIGNOR-248625 |
| PTPRR | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 11493009 | SIGNOR-248840 |
| MAP2K1 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-236447 |
| MAP2K2 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-86709 |
| MAP2K1 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-235937 |
| RET | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 16153436 | SIGNOR-140294 |
| SGK1 | phosphorylation up-regulates → | MAPK1 PSer29 | phosphorylation up-regulates → | MAPK1 | 19447520 | SIGNOR-276223 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-249415 |
| MAP2K2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-258996 |
| PP1 | dephosphorylation down-regulates | MAPK1 | SIGNOR-264664 |
| AKT1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-279136 |
| PRKCH | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-261910 |
| DUSP5 | dephosphorylation down-regulates | MAPK1 | SIGNOR-134049 |
| PPP2CA | dephosphorylation down-regulates | MAPK1 | SIGNOR-143052 |
| PTPN7 | dephosphorylation down-regulates | MAPK1 | SIGNOR-69448 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248465 |
| PBK | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-278417 |
| PPP2CA | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-103159 |
| PTPRE | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248449 |
| PPP1CA | dephosphorylation down-regulates | MAPK1 | SIGNOR-103152 |
| DUSP3 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248536 |
| MAPK1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-249414 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-101276 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248483 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248708 |
| MEK1/2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-258990 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248464 |
| PTPRJ | dephosphorylation down-regulates | MAPK1 | SIGNOR-101279 |
| DUSP5 | dephosphorylation down-regulates | MAPK1 | SIGNOR-67355 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248484 |
| MEK1/2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-244788 |
| DUSP1 | dephosphorylation down-regulates | MAPK1 | SIGNOR-73614 |
| MEK1/2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-244792 |
| DUSP9 | dephosphorylation down-regulates | MAPK1 | SIGNOR-176586 |
| DUSP4 | dephosphorylation down-regulates | MAPK1 | SIGNOR-40926 |
| DUSP6 | dephosphorylation down-regulates | MAPK1 | SIGNOR-103146 |
| MEK1/2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-244795 |
| DUSP7 | dephosphorylation down-regulates | MAPK1 | SIGNOR-60871 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248718 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-235940 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248717 |
| MAP2K2 | phosphorylation → up-regulates | MAPK1 | SIGNOR-86713 |
| DUSP6 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-277006 |
| PTPRJ | dephosphorylation down-regulates | MAPK1 | SIGNOR-161536 |
| PTPRB | dephosphorylation down-regulates | MAPK1 | SIGNOR-173000 |
| PPP2CB | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248590 |
| PTPRE | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248448 |
| PPP2CA | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248625 |
| DUSP2 | dephosphorylation down-regulates | MAPK1 | SIGNOR-40915 |
| PTPRR | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248840 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-236447 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-258993 |
| MAP2K2 | phosphorylation → up-regulates | MAPK1 | SIGNOR-86709 |
| RIPK2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-279106 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-235937 |
| RET | phosphorylation → up-regulates | MAPK1 | SIGNOR-140294 |
| PPP2CA | dephosphorylation down-regulates | MAPK1 | SIGNOR-166655 |
| SGK1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-276223 |
| STK33 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-279351 |