| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP3 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10224087 | SIGNOR-248536 |
| PTPN7 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 16226275 | SIGNOR-248483 |
| PTPRJ | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 19494114 | SIGNOR-248708 |
| MEK1/2 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 11971971 | SIGNOR-244788 |
| DUSP4 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248718 |
| MAP2K2 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 11971971 | SIGNOR-86713 |
| MAP2K1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 11971971 | SIGNOR-235937 |
| DUSP1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248465 |
| PTPN7 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10702794 | SIGNOR-248484 |
| RET | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 16153436 | SIGNOR-140294 |
| MAPK1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 1712480 | SIGNOR-249415 |
| PTPRE | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 12754301 | SIGNOR-248448 |
| PTPRR | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 11493009 | SIGNOR-248840 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP3 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 10224087 | SIGNOR-248536 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 16226275 | SIGNOR-248483 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-248708 |
| MEK1/2 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-244788 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248718 |
| MAP2K2 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-86713 |
| MAP2K1 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-235937 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248465 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 10702794 | SIGNOR-248484 |
| RET | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 16153436 | SIGNOR-140294 |
| MAPK1 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 1712480 | SIGNOR-249415 |
| PTPRE | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 12754301 | SIGNOR-248448 |
| PTPRR | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 11493009 | SIGNOR-248840 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DUSP3 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248536 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248483 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248708 |
| MEK1/2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-244788 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248718 |
| MAP2K2 | phosphorylation → up-regulates | MAPK1 | SIGNOR-86713 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-235937 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248465 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248484 |
| RET | phosphorylation → up-regulates | MAPK1 | SIGNOR-140294 |
| MAPK1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-249415 |
| PTPRE | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248448 |
| PTPRR | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248840 |
