| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 12840032 | SIGNOR-103159 |
| PTPRE | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 12754301 | SIGNOR-248449 |
| DUSP1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248464 |
| MEK1/2 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 11971971 | SIGNOR-244792 |
| DUSP4 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248717 |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7780739 | SIGNOR-248625 |
| PPP2CB | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7780739 | SIGNOR-248590 |
| MAPK1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 1712480 | SIGNOR-249414 |
| PPP2CA | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates | 16456541 | SIGNOR-143052 |
| MAP2K1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 11971971 | SIGNOR-236447 |
| MAP2K2 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 11971971 | SIGNOR-86709 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 12840032 | SIGNOR-103159 |
| PTPRE | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 12754301 | SIGNOR-248449 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248464 |
| MEK1/2 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-244792 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248717 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7780739 | SIGNOR-248625 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7780739 | SIGNOR-248590 |
| MAPK1 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 1712480 | SIGNOR-249414 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 16456541 | SIGNOR-143052 |
| MAP2K1 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-236447 |
| MAP2K2 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-86709 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-103159 |
| PTPRE | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248449 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248464 |
| MEK1/2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-244792 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248717 |
| PPP2CA | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248625 |
| PPP2CB | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248590 |
| MAPK1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-249414 |
| PPP2CA | dephosphorylation down-regulates | MAPK1 | SIGNOR-143052 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-236447 |
| MAP2K2 | phosphorylation → up-regulates | MAPK1 | SIGNOR-86709 |
