| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | MAPK1 | Tyr205 | IMLNSKGyTKSIDIW | dephosphorylation down-regulates | 19494114 | SIGNOR-161536 |
| PTPRJ | MAPK1 | Tyr205 | IMLNSKGyTKSIDIW | dephosphorylation down-regulates activity | 19494114 | SIGNOR-101276 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr205 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-161536 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MAPK1 PTyr205 | dephosphorylation up-regulates → | MAPK1 | 19494114 | SIGNOR-101276 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation![]() down-regulates | MAPK1 | SIGNOR-161536 |
| PTPRJ | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-101276 |