Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK4	RBL1	Ser964 View in OncoXplorer	MMDAPPLsPFPHIKQ	phosphorylation up-regulates activity	12006580	SIGNOR-250764
CDK4	RBL1	Thr369 View in OncoXplorer	KRSFAPStPLTGRRY	phosphorylation up-regulates activity	12006580	SIGNOR-250765
CDK4	RBL1	Ser650 View in OncoXplorer	SVHERYSsPTAGSAK	phosphorylation up-regulates activity	12006580	SIGNOR-250763
PPP2CA	RBL1	–		dephosphorylation up-regulates	15467457	SIGNOR-129749

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK4	phosphorylation up-regulates →	RBL1 PSer964	phosphorylation up-regulates →	RBL1	12006580	SIGNOR-250764
CDK4	phosphorylation up-regulates →	RBL1 PThr369	phosphorylation up-regulates →	RBL1	12006580	SIGNOR-250765
CDK4	phosphorylation up-regulates →	RBL1 PSer650	phosphorylation up-regulates →	RBL1	12006580	SIGNOR-250763

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK4	phosphorylation → up-regulates activity	RBL1	SIGNOR-250764
CDK4	phosphorylation → up-regulates activity	RBL1	SIGNOR-250765
CDK4	phosphorylation → up-regulates activity	RBL1	SIGNOR-250763
PPP2CA	dephosphorylation → up-regulates	RBL1	SIGNOR-129749