Entity Details

Name PTPRM
ID P28827
Role phosphatase
Enzymatic Domains
MAM 22-184
PROSITE-ProRule
Ig-like C2-type 186-277
Fibronectin type-III 1 284-379
PROSITE-ProRule
Fibronectin type-III 2 382-480
PROSITE-ProRule
Fibronectin type-III 3 482-587
PROSITE-ProRule
Fibronectin type-III 4 589-671
PROSITE-ProRule
Tyrosine-protein phosphatase 1 900-1154
PROSITE-ProRule
Tyrosine-protein phosphatase 2 1186-1448
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPRMCTNND1–dephosphorylation
down-regulates quantity		21998202SIGNOR-277042
PTPRMSTAT3Tyr705DPGSAAPyLKTKFICdephosphorylation
down-regulates activity		31900385SIGNOR-277016
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPRMdephosphorylation
down-regulates
⊣
STAT3
PTyr705		dephosphorylation
up-regulates
→		STAT331900385SIGNOR-277016
Regulator Mechanism/Effect Target SIGNOR-ID
PTPRMdephosphorylation
→
down-regulates quantity 		CTNND1SIGNOR-277042
PTPRMdephosphorylation
→
down-regulates activity 		STAT3SIGNOR-277016