| Name | EPHA2 |
| ID | P29317 |
| Role | kinase |
| Enzymatic Domains |
Eph LBD 28-206 PROSITE-ProRule
Fibronectin type-III 1 328-432 PROSITE-ProRule
Fibronectin type-III 2 438-529 PROSITE-ProRule
Protein kinase 613-875 PROSITE-ProRule
SAM 904-968 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EPHA2 | CLDN4 | Tyr208 | RSAAASNyV | phosphorylation down-regulates activity | 16236711 | SIGNOR-262859 |
| EPHA2 | YES1 | Tyr426 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 33941853 | SIGNOR-277556 |
| EPHA2 | PLCG1 | – | phosphorylation up-regulates activity | 32753469 | SIGNOR-279708 | |
| EPHA2 | EPHA2 | Tyr588 | QLKPLKTyVDPHTYE | phosphorylation up-regulates | 18387945 | SIGNOR-178169 |
| EPHA2 | EPHA2 | Tyr735 | KYLANMNyVHRDLAA | phosphorylation up-regulates | 18387945 | SIGNOR-178177 |
| EPHA2 | EPHA2 | Tyr772 | EDDPEATyTTSGGKI | phosphorylation up-regulates | 18387945 | SIGNOR-178181 |
| EPHA2 | EPHA2 | Tyr594 | TYVDPHTyEDPNQAV | phosphorylation up-regulates activity | 18387945 | SIGNOR-178173 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EPHA2 | phosphorylation up-regulates → | CLDN4 PTyr208 | phosphorylation down-regulates ⊣ | CLDN4 | 16236711 | SIGNOR-262859 |
| EPHA2 | phosphorylation up-regulates → | YES1 PTyr426 | phosphorylation up-regulates → | YES1 | 33941853 | SIGNOR-277556 |
| EPHA2 | phosphorylation up-regulates → | EPHA2 PTyr588 | phosphorylation up-regulates → | EPHA2 | 18387945 | SIGNOR-178169 |
| EPHA2 | phosphorylation up-regulates → | EPHA2 PTyr735 | phosphorylation up-regulates → | EPHA2 | 18387945 | SIGNOR-178177 |
| EPHA2 | phosphorylation up-regulates → | EPHA2 PTyr772 | phosphorylation up-regulates → | EPHA2 | 18387945 | SIGNOR-178181 |
| EPHA2 | phosphorylation up-regulates → | EPHA2 PTyr594 | phosphorylation up-regulates → | EPHA2 | 18387945 | SIGNOR-178173 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EPHA2 | phosphorylation → down-regulates activity | CLDN4 | SIGNOR-262859 |
| EPHA2 | phosphorylation → up-regulates activity | YES1 | SIGNOR-277556 |
| EPHA2 | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-279708 |
| EPHA2 | phosphorylation → up-regulates | EPHA2 | SIGNOR-178169 |
| EPHA2 | phosphorylation → up-regulates | EPHA2 | SIGNOR-178177 |
| EPHA2 | phosphorylation → up-regulates | EPHA2 | SIGNOR-178181 |
| EPHA2 | phosphorylation → up-regulates activity | EPHA2 | SIGNOR-178173 |