Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ACP1	EPHA2	Tyr772 View in OncoXplorer	EDDPEATyTTSGGKI	dephosphorylation down-regulates activity	21538645	SIGNOR-246027
EPHA2	EPHA2	Tyr594 View in OncoXplorer	TYVDPHTyEDPNQAV	phosphorylation up-regulates activity	18387945	SIGNOR-178173
ACP1	EPHA2	Tyr960	GHQKRIAySLLGLKD	dephosphorylation down-regulates activity	21538645	SIGNOR-246023
RPS6KA1	EPHA2	Ser897 View in OncoXplorer	RVSIRLPsTSGSEGV	phosphorylation up-regulates activity	32574556	SIGNOR-280113
ACP1	EPHA2	Tyr575 View in OncoXplorer	RQSPEDVyFSKSEQL	dephosphorylation down-regulates activity	21538645	SIGNOR-246031
EPHA2	EPHA2	Tyr772 View in OncoXplorer	EDDPEATyTTSGGKI	phosphorylation up-regulates	18387945	SIGNOR-178181
AKT1	EPHA2	Ser897 View in OncoXplorer	RVSIRLPsTSGSEGV	phosphorylation up-regulates activity	35869144	SIGNOR-279787
EPHA2	EPHA2	Tyr588 View in OncoXplorer	QLKPLKTyVDPHTYE	phosphorylation up-regulates	18387945	SIGNOR-178169
ACP1	EPHA2	Tyr594 View in OncoXplorer	TYVDPHTyEDPNQAV	dephosphorylation down-regulates activity	21538645	SIGNOR-246039
EPHA2	EPHA2	Tyr735	KYLANMNyVHRDLAA	phosphorylation up-regulates	18387945	SIGNOR-178177
SRC	EPHA2	Tyr594 View in OncoXplorer	TYVDPHTyEDPNQAV	phosphorylation up-regulates activity	24457997	SIGNOR-246104
ACP1	EPHA2	Tyr588 View in OncoXplorer	QLKPLKTyVDPHTYE	dephosphorylation down-regulates activity	21538645	SIGNOR-246035

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ACP1	dephosphorylation down-regulates ⊣	EPHA2 PTyr772	dephosphorylation up-regulates →	EPHA2	21538645	SIGNOR-246027
EPHA2	phosphorylation up-regulates →	EPHA2 PTyr594	phosphorylation up-regulates →	EPHA2	18387945	SIGNOR-178173
ACP1	dephosphorylation down-regulates ⊣	EPHA2 PTyr960	dephosphorylation up-regulates →	EPHA2	21538645	SIGNOR-246023
RPS6KA1	phosphorylation up-regulates →	EPHA2 PSer897	phosphorylation up-regulates →	EPHA2	32574556	SIGNOR-280113
ACP1	dephosphorylation down-regulates ⊣	EPHA2 PTyr575	dephosphorylation up-regulates →	EPHA2	21538645	SIGNOR-246031
EPHA2	phosphorylation up-regulates →	EPHA2 PTyr772	phosphorylation up-regulates →	EPHA2	18387945	SIGNOR-178181
AKT1	phosphorylation up-regulates →	EPHA2 PSer897	phosphorylation up-regulates →	EPHA2	35869144	SIGNOR-279787
EPHA2	phosphorylation up-regulates →	EPHA2 PTyr588	phosphorylation up-regulates →	EPHA2	18387945	SIGNOR-178169
ACP1	dephosphorylation down-regulates ⊣	EPHA2 PTyr594	dephosphorylation up-regulates →	EPHA2	21538645	SIGNOR-246039
EPHA2	phosphorylation up-regulates →	EPHA2 PTyr735	phosphorylation up-regulates →	EPHA2	18387945	SIGNOR-178177
SRC	phosphorylation up-regulates →	EPHA2 PTyr594	phosphorylation up-regulates →	EPHA2	24457997	SIGNOR-246104
ACP1	dephosphorylation down-regulates ⊣	EPHA2 PTyr588	dephosphorylation up-regulates →	EPHA2	21538645	SIGNOR-246035

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ACP1	dephosphorylation → down-regulates activity	EPHA2	SIGNOR-246027
EPHA2	phosphorylation → up-regulates activity	EPHA2	SIGNOR-178173
ACP1	dephosphorylation → down-regulates activity	EPHA2	SIGNOR-246023
RPS6KA1	phosphorylation → up-regulates activity	EPHA2	SIGNOR-280113
ACP1	dephosphorylation → down-regulates activity	EPHA2	SIGNOR-246031
EPHA2	phosphorylation → up-regulates	EPHA2	SIGNOR-178181
AKT1	phosphorylation → up-regulates activity	EPHA2	SIGNOR-279787
EPHA2	phosphorylation → up-regulates	EPHA2	SIGNOR-178169
ACP1	dephosphorylation → down-regulates activity	EPHA2	SIGNOR-246039
EPHA2	phosphorylation → up-regulates	EPHA2	SIGNOR-178177
SRC	phosphorylation → up-regulates activity	EPHA2	SIGNOR-246104
ACP1	dephosphorylation → down-regulates activity	EPHA2	SIGNOR-246035