| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EPHA2 | EPHA2 | Tyr588 | QLKPLKTyVDPHTYE | phosphorylation up-regulates | 18387945 | SIGNOR-178169 |
| ACP1 | EPHA2 | Tyr588 | QLKPLKTyVDPHTYE | dephosphorylation down-regulates activity | 21538645 | SIGNOR-246035 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EPHA2 | phosphorylation up-regulates → | EPHA2 PTyr588 | phosphorylation up-regulates → | EPHA2 | 18387945 | SIGNOR-178169 |
| ACP1 | dephosphorylation down-regulates ⊣ | EPHA2 PTyr588 | dephosphorylation up-regulates → | EPHA2 | 21538645 | SIGNOR-246035 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EPHA2 | phosphorylation → up-regulates | EPHA2 | SIGNOR-178169 |
| ACP1 | dephosphorylation → down-regulates activity | EPHA2 | SIGNOR-246035 |
