| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACP1 | EPHA2 | Tyr594 | TYVDPHTyEDPNQAV | dephosphorylation down-regulates activity | 21538645 | SIGNOR-246039 |
| SRC | EPHA2 | Tyr594 | TYVDPHTyEDPNQAV | phosphorylation up-regulates activity | 24457997 | SIGNOR-246104 |
| EPHA2 | EPHA2 | Tyr594 | TYVDPHTyEDPNQAV | phosphorylation up-regulates activity | 18387945 | SIGNOR-178173 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACP1 | dephosphorylation down-regulates ⊣ | EPHA2 PTyr594 | dephosphorylation up-regulates → | EPHA2 | 21538645 | SIGNOR-246039 |
| SRC | phosphorylation up-regulates → | EPHA2 PTyr594 | phosphorylation up-regulates → | EPHA2 | 24457997 | SIGNOR-246104 |
| EPHA2 | phosphorylation up-regulates → | EPHA2 PTyr594 | phosphorylation up-regulates → | EPHA2 | 18387945 | SIGNOR-178173 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ACP1 | dephosphorylation → down-regulates activity | EPHA2 | SIGNOR-246039 |
| SRC | phosphorylation → up-regulates activity | EPHA2 | SIGNOR-246104 |
| EPHA2 | phosphorylation → up-regulates activity | EPHA2 | SIGNOR-178173 |