Entity Details

Name EPHA3
ID P29320
Role kinase
Enzymatic Domains
Eph LBD 29-207
PROSITE-ProRule
Fibronectin type-III 1 325-435
PROSITE-ProRule
Fibronectin type-III 2 436-531
PROSITE-ProRule
Protein kinase 621-882
PROSITE-ProRule
SAM 911-975
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
EPHA3ARTyr535MDSYSGPyGDMRLETphosphorylation
up-regulates activity		20570899SIGNOR-279370
EPHA3ARTyr552DHVLPIDyYFPPQKTphosphorylation
up-regulates activity		20570899SIGNOR-279371
EPHA3EPHA3Tyr596KLPGLRTyVDPHTYEphosphorylation
up-regulates activity		11870224SIGNOR-251115
EPHA3EPHA3Tyr602TYVDPHTyEDPTQAVphosphorylation
up-regulates activity		11870224SIGNOR-251116
EPHA3EPHA3Tyr779EDDPEAAyTTRGGKIphosphorylation
up-regulates activity		11870224SIGNOR-251117
EPHA3PAK1Tyr153TDKSAEDyNSSNALNphosphorylation
up-regulates activity		26944939SIGNOR-278398
EPHA3UXS1–phosphorylation
up-regulates activity		25505462SIGNOR-280006
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
EPHA3phosphorylation
up-regulates
→
AR
PTyr535		phosphorylation
up-regulates
→		AR20570899SIGNOR-279370
EPHA3phosphorylation
up-regulates
→
AR
PTyr552		phosphorylation
up-regulates
→		AR20570899SIGNOR-279371
EPHA3phosphorylation
up-regulates
→
EPHA3
PTyr596		phosphorylation
up-regulates
→		EPHA311870224SIGNOR-251115
EPHA3phosphorylation
up-regulates
→
EPHA3
PTyr602		phosphorylation
up-regulates
→		EPHA311870224SIGNOR-251116
EPHA3phosphorylation
up-regulates
→
EPHA3
PTyr779		phosphorylation
up-regulates
→		EPHA311870224SIGNOR-251117
EPHA3phosphorylation
up-regulates
→
PAK1
PTyr153		phosphorylation
up-regulates
→		PAK126944939SIGNOR-278398
Regulator Mechanism/Effect Target SIGNOR-ID
EPHA3phosphorylation
→
up-regulates activity 		ARSIGNOR-279370
EPHA3phosphorylation
→
up-regulates activity 		ARSIGNOR-279371
EPHA3phosphorylation
→
up-regulates activity 		EPHA3SIGNOR-251115
EPHA3phosphorylation
→
up-regulates activity 		EPHA3SIGNOR-251116
EPHA3phosphorylation
→
up-regulates activity 		EPHA3SIGNOR-251117
EPHA3phosphorylation
→
up-regulates activity 		PAK1SIGNOR-278398
EPHA3phosphorylation
→
up-regulates activity 		UXS1SIGNOR-280006