Entity Details

Name EPHA3
ID P29320
Role substrate
Enzymatic Domains
Eph LBD 29-207
PROSITE-ProRule
Fibronectin type-III 1 325-435
PROSITE-ProRule
Fibronectin type-III 2 436-531
PROSITE-ProRule
Protein kinase 621-882
PROSITE-ProRule
SAM 911-975
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
EPHA3EPHA3Tyr602TYVDPHTyEDPTQAVphosphorylation
up-regulates activity		11870224SIGNOR-251116
EPHA3EPHA3Tyr779EDDPEAAyTTRGGKIphosphorylation
up-regulates activity		11870224SIGNOR-251117
EPHA3EPHA3Tyr596KLPGLRTyVDPHTYEphosphorylation
up-regulates activity		11870224SIGNOR-251115
PTPN1EPHA3Tyr779EDDPEAAyTTRGGKIdephosphorylation
down-regulates activity		21135139SIGNOR-248426
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
EPHA3phosphorylation
up-regulates
→
EPHA3
PTyr602		phosphorylation
up-regulates
→		EPHA311870224SIGNOR-251116
EPHA3phosphorylation
up-regulates
→
EPHA3
PTyr779		phosphorylation
up-regulates
→		EPHA311870224SIGNOR-251117
EPHA3phosphorylation
up-regulates
→
EPHA3
PTyr596		phosphorylation
up-regulates
→		EPHA311870224SIGNOR-251115
PTPN1dephosphorylation
down-regulates
⊣
EPHA3
PTyr779		dephosphorylation
up-regulates
→		EPHA321135139SIGNOR-248426
Regulator Mechanism/Effect Target SIGNOR-ID
EPHA3phosphorylation
→
up-regulates activity 		EPHA3SIGNOR-251116
EPHA3phosphorylation
→
up-regulates activity 		EPHA3SIGNOR-251117
EPHA3phosphorylation
→
up-regulates activity 		EPHA3SIGNOR-251115
PTPN1dephosphorylation
→
down-regulates activity 		EPHA3SIGNOR-248426