| Name | PTPN6 |
| ID | P29350 |
| Role | phosphatase |
| Enzymatic Domains |
SH2 1 4-100 PROSITE-ProRule
SH2 2 110-213 PROSITE-ProRule
Tyrosine-protein phosphatase 244-515 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | MAP3K7 | – | dephosphorylation down-regulates activity | 31130074 | SIGNOR-277128 | |
| PTPN6 | JAK2 | – | dephosphorylation down-regulates activity | 8943354 | SIGNOR-248466 | |
| PTPN6 | NFAT5 | Tyr143 | PKRHTVLyISPPPED | dephosphorylation down-regulates activity | 20351292 | SIGNOR-248467 |
| PTPN6 | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation down-regulates | 9733788 | SIGNOR-59965 |
| PTPN6 | NTRK1 | Tyr680 | RDIYSTDyYRVGGRT | dephosphorylation down-regulates activity | 14662744 | SIGNOR-248468 |
| PTPN6 | NTRK1 | Tyr681 | DIYSTDYyRVGGRTM | dephosphorylation down-regulates activity | 14662744 | SIGNOR-248469 |
| PTPN6 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75926 |
| PTPN6 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75930 |
| PTPN6 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-75934 |
| PTPN6 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75938 |
| PTPN6 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 11294838 | SIGNOR-106604 |
| PTPN6 | LYN | Tyr397 | RVIEDNEyTAREGAK | dephosphorylation down-regulates activity | 15537644 | SIGNOR-248471 |
| PTPN6 | ROS1 | Tyr2274 | KNREGLNyMVLATEC | dephosphorylation down-regulates | 11266449 | SIGNOR-105919 |
| PTPN6 | ROS1 | – | dephosphorylation down-regulates | 11266449 | SIGNOR-105922 | |
| PTPN6 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248472 |
| PTPN6 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 9261115 | SIGNOR-248473 |
| PTPN6 | PKM | Tyr105 | FASDPILyRPVAVAL | dephosphorylation down-regulates activity | 26959741 | SIGNOR-276997 |
| PTPN6 | IL2RB | – | dephosphorylation down-regulates | 9520455 | SIGNOR-55989 | |
| PTPN6 | VAV1 | – | dephosphorylation down-regulates activity | 30567306 | SIGNOR-277171 | |
| PTPN6 | CD72 | – | dephosphorylation down-regulates | 9740800 | SIGNOR-60155 | |
| PTPN6 | JAK1 | – | dephosphorylation down-regulates | 14624462 | SIGNOR-119197 | |
| PTPN6 | CSF2RB | Tyr628 | PPPGSLEyLCLPAGG | dephosphorylation down-regulates | 11812650 | SIGNOR-114597 |
| PTPN6 | CSF2RB | Tyr628 | PPPGSLEyLCLPAGG | dephosphorylation down-regulates | 9162089 | SIGNOR-48561 |
| PTPN6 | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | dephosphorylation down-regulates quantity by destabilization | 20840866 | SIGNOR-277014 |
| PTPN6 | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | dephosphorylation down-regulates quantity by destabilization | 20840866 | SIGNOR-277013 |
| PTPN6 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18377662 | SIGNOR-248474 |
| PTPN6 | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 18377662 | SIGNOR-248475 |
| PTPN6 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation unknown | 18840653 | SIGNOR-248476 |
| PTPN6 | STAT3 | – | dephosphorylation down-regulates | 18508557 | SIGNOR-178699 | |
| PTPN6 | ZAP70 | – | dephosphorylation down-regulates | 10458769 | SIGNOR-70237 | |
| PTPN6 | SYK | – | dephosphorylation down-regulates | 10458769 | SIGNOR-70234 | |
| PTPN6 | JAK3 | – | dephosphorylation up-regulates | 11021818 | SIGNOR-82764 | |
| PTPN6 | ACTG1 | Tyr218 | DIKEKLCyVALDFEQ | dephosphorylation down-regulates | 12646642 | SIGNOR-99565 |
| PTPN6 | SH3BP2 | – | dephosphorylation down-regulates | 16649996 | SIGNOR-146508 | |
| PTPN6 | SH3BP2 | Tyr448 | GDDSDEDyEKVPLPN | dephosphorylation down-regulates activity | 16649996 | SIGNOR-277172 |
| PTPN6 | KCNH2 | – | dephosphorylation down-regulates | 12361947 | SIGNOR-94007 | |
| PTPN6 | TRAF3 | Tyr116 | EILALQIyCRNESRG | dephosphorylation down-regulates activity | 32779804 | SIGNOR-277527 |
| PTPN6 | TRAF3 | Tyr446 | SLYSQPFyTGYFGYK | dephosphorylation down-regulates activity | 32779804 | SIGNOR-277526 |
| PTPN6 | CTTN | Tyr421 | RLPSSPVyEDAASFK | dephosphorylation down-regulates activity | 34088320 | SIGNOR-277003 |
| PTPN6 | PTK2B | Tyr402 | CSIESDIyAEIPDET | dephosphorylation down-regulates | 10521452 | SIGNOR-71414 |
| PTPN6 | CASP8 | Tyr380 | TDSEEQPyLEMDLSS | dephosphorylation up-regulates activity | 18086677 | SIGNOR-248477 |
| PTPN6 | CASP8 | Tyr448 | TILTEVNyEVSNKDD | dephosphorylation up-regulates activity | 18086677 | SIGNOR-248478 |
| PTPN6 | TRPV1 | – | dephosphorylation down-regulates activity | 25790452 | SIGNOR-277129 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | NFAT5 PTyr143 | dephosphorylation up-regulates → | NFAT5 | 20351292 | SIGNOR-248467 |
| PTPN6 | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation up-regulates → | EGFR | 9733788 | SIGNOR-59965 |
| PTPN6 | dephosphorylation down-regulates ⊣ | NTRK1 PTyr680 | dephosphorylation up-regulates → | NTRK1 | 14662744 | SIGNOR-248468 |
| PTPN6 | dephosphorylation down-regulates ⊣ | NTRK1 PTyr681 | dephosphorylation up-regulates → | NTRK1 | 14662744 | SIGNOR-248469 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75926 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75930 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75934 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75938 |
| PTPN6 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 11294838 | SIGNOR-106604 |
| PTPN6 | dephosphorylation down-regulates ⊣ | LYN PTyr397 | dephosphorylation up-regulates → | LYN | 15537644 | SIGNOR-248471 |
| PTPN6 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2274 | dephosphorylation up-regulates → | ROS1 | 11266449 | SIGNOR-105919 |
| PTPN6 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248472 |
| PTPN6 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 9261115 | SIGNOR-248473 |
| PTPN6 | dephosphorylation down-regulates ⊣ | PKM PTyr105 | dephosphorylation up-regulates → | PKM | 26959741 | SIGNOR-276997 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CSF2RB PTyr628 | dephosphorylation up-regulates → | CSF2RB | 11812650 | SIGNOR-114597 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CSF2RB PTyr628 | dephosphorylation up-regulates → | CSF2RB | 9162089 | SIGNOR-48561 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTNNB1 PTyr654 | dephosphorylation up-regulates → | CTNNB1 | 20840866 | SIGNOR-277014 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTNNB1 PTyr86 | dephosphorylation up-regulates → | CTNNB1 | 20840866 | SIGNOR-277013 |
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18377662 | SIGNOR-248474 |
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 18377662 | SIGNOR-248475 |
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248476 |
| PTPN6 | dephosphorylation down-regulates ⊣ | ACTG1 PTyr218 | dephosphorylation up-regulates → | ACTG1 | 12646642 | SIGNOR-99565 |
| PTPN6 | dephosphorylation down-regulates ⊣ | SH3BP2 PTyr448 | dephosphorylation up-regulates → | SH3BP2 | 16649996 | SIGNOR-277172 |
| PTPN6 | dephosphorylation down-regulates ⊣ | TRAF3 PTyr116 | dephosphorylation up-regulates → | TRAF3 | 32779804 | SIGNOR-277527 |
| PTPN6 | dephosphorylation down-regulates ⊣ | TRAF3 PTyr446 | dephosphorylation up-regulates → | TRAF3 | 32779804 | SIGNOR-277526 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTTN PTyr421 | dephosphorylation up-regulates → | CTTN | 34088320 | SIGNOR-277003 |
| PTPN6 | dephosphorylation down-regulates ⊣ | PTK2B PTyr402 | dephosphorylation up-regulates → | PTK2B | 10521452 | SIGNOR-71414 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CASP8 PTyr380 | dephosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-248477 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CASP8 PTyr448 | dephosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-248478 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | MAP3K7 | SIGNOR-277128 |
| PTPN6 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248466 |
| PTPN6 | dephosphorylation → down-regulates activity | NFAT5 | SIGNOR-248467 |
| PTPN6 | dephosphorylation down-regulates | EGFR | SIGNOR-59965 |
| PTPN6 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-248468 |
| PTPN6 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-248469 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75926 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75930 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75934 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75938 |
| PTPN6 | dephosphorylation → down-regulates activity | LCK | SIGNOR-106604 |
| PTPN6 | dephosphorylation → down-regulates activity | LYN | SIGNOR-248471 |
| PTPN6 | dephosphorylation down-regulates | ROS1 | SIGNOR-105919 |
| PTPN6 | dephosphorylation down-regulates | ROS1 | SIGNOR-105922 |
| PTPN6 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248472 |
| PTPN6 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248473 |
| PTPN6 | dephosphorylation → down-regulates activity | PKM | SIGNOR-276997 |
| PTPN6 | dephosphorylation down-regulates | IL2RB | SIGNOR-55989 |
| PTPN6 | dephosphorylation → down-regulates activity | VAV1 | SIGNOR-277171 |
| PTPN6 | dephosphorylation down-regulates | CD72 | SIGNOR-60155 |
| PTPN6 | dephosphorylation down-regulates | JAK1 | SIGNOR-119197 |
| PTPN6 | dephosphorylation down-regulates | CSF2RB | SIGNOR-114597 |
| PTPN6 | dephosphorylation down-regulates | CSF2RB | SIGNOR-48561 |
| PTPN6 | dephosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-277014 |
| PTPN6 | dephosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-277013 |
| PTPN6 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248474 |
| PTPN6 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248475 |
| PTPN6 | dephosphorylation → unknown | KDR | SIGNOR-248476 |
| PTPN6 | dephosphorylation down-regulates | STAT3 | SIGNOR-178699 |
| PTPN6 | dephosphorylation down-regulates | ZAP70 | SIGNOR-70237 |
| PTPN6 | dephosphorylation down-regulates | SYK | SIGNOR-70234 |
| PTPN6 | dephosphorylation → up-regulates | JAK3 | SIGNOR-82764 |
| PTPN6 | dephosphorylation down-regulates | ACTG1 | SIGNOR-99565 |
| PTPN6 | dephosphorylation down-regulates | SH3BP2 | SIGNOR-146508 |
| PTPN6 | dephosphorylation → down-regulates activity | SH3BP2 | SIGNOR-277172 |
| PTPN6 | dephosphorylation down-regulates | KCNH2 | SIGNOR-94007 |
| PTPN6 | dephosphorylation → down-regulates activity | TRAF3 | SIGNOR-277527 |
| PTPN6 | dephosphorylation → down-regulates activity | TRAF3 | SIGNOR-277526 |
| PTPN6 | dephosphorylation → down-regulates activity | CTTN | SIGNOR-277003 |
| PTPN6 | dephosphorylation down-regulates | PTK2B | SIGNOR-71414 |
| PTPN6 | dephosphorylation → up-regulates activity | CASP8 | SIGNOR-248477 |
| PTPN6 | dephosphorylation → up-regulates activity | CASP8 | SIGNOR-248478 |
| PTPN6 | dephosphorylation → down-regulates activity | TRPV1 | SIGNOR-277129 |