| Name | PTPN6 |
| ID | P29350 |
| Role | substrate |
| Enzymatic Domains |
SH2 1 4-100 PROSITE-ProRule
SH2 2 110-213 PROSITE-ProRule
Tyrosine-protein phosphatase 244-515 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates | 8114715 | SIGNOR-36121 |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation unknown | 8692915 | SIGNOR-246231 |
| PRKCA | PTPN6 | Ser591 | DKEKSKGsLKRK | phosphorylation down-regulates | 15269224 | SIGNOR-126876 |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates activity | 8692915 | SIGNOR-251433 |
| PRKG2 | PTPN6 | Ser556 | HAKASRTsSKHKEDV | phosphorylation up-regulates activity | 21177494 | SIGNOR-276286 |
| INSR | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates | 7512963 | SIGNOR-26870 |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation unknown | 12468540 | SIGNOR-246240 |
| PRKCQ | PTPN6 | Ser591 | DKEKSKGsLKRK | phosphorylation down-regulates activity | 35258455 | SIGNOR-277590 |
| CDK2 | PTPN6 | – | phosphorylation down-regulates quantity by destabilization | 18617527 | SIGNOR-279147 | |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates activity | 8692915 | SIGNOR-260821 |
| PRKG2 | PTPN6 | Ser557 | AKASRTSsKHKEDVY | phosphorylation up-regulates activity | 21177494 | SIGNOR-276287 |
| PRKG2 | PTPN6 | Ser553 | KNAHAKAsRTSSKHK | phosphorylation up-regulates activity | 21177494 | SIGNOR-276288 |
| LYN | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates activity | 10574931 | SIGNOR-251409 |
| LCK | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 8114715 | SIGNOR-251387 |
| ABL1 | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 8692915 | SIGNOR-260820 |
| ABL1 | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 12468540 | SIGNOR-246236 |
| SRC | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates | 14699166 | SIGNOR-120488 |
| FYN | PTPN6 | Ser591 | DKEKSKGsLKRK | phosphorylation up-regulates activity | 28811476 | SIGNOR-279716 |
| SRC | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates | 14699166 | SIGNOR-120492 |
| ABL1 | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 8692915 | SIGNOR-246227 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 8114715 | SIGNOR-36121 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation down-regulates ⊣ | PTPN6 | 8692915 | SIGNOR-246231 |
| PRKCA | phosphorylation up-regulates → | PTPN6 PSer591 | phosphorylation down-regulates ⊣ | PTPN6 | 15269224 | SIGNOR-126876 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-251433 |
| PRKG2 | phosphorylation up-regulates → | PTPN6 PSer556 | phosphorylation up-regulates → | PTPN6 | 21177494 | SIGNOR-276286 |
| INSR | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 7512963 | SIGNOR-26870 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation down-regulates ⊣ | PTPN6 | 12468540 | SIGNOR-246240 |
| PRKCQ | phosphorylation up-regulates → | PTPN6 PSer591 | phosphorylation down-regulates ⊣ | PTPN6 | 35258455 | SIGNOR-277590 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-260821 |
| PRKG2 | phosphorylation up-regulates → | PTPN6 PSer557 | phosphorylation up-regulates → | PTPN6 | 21177494 | SIGNOR-276287 |
| PRKG2 | phosphorylation up-regulates → | PTPN6 PSer553 | phosphorylation up-regulates → | PTPN6 | 21177494 | SIGNOR-276288 |
| LYN | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 10574931 | SIGNOR-251409 |
| LCK | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 8114715 | SIGNOR-251387 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-260820 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 12468540 | SIGNOR-246236 |
| SRC | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 14699166 | SIGNOR-120488 |
| FYN | phosphorylation up-regulates → | PTPN6 PSer591 | phosphorylation up-regulates → | PTPN6 | 28811476 | SIGNOR-279716 |
| SRC | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 14699166 | SIGNOR-120492 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-246227 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates | PTPN6 | SIGNOR-36121 |
| ABL1 | phosphorylation → unknown | PTPN6 | SIGNOR-246231 |
| PRKCA | phosphorylation down-regulates | PTPN6 | SIGNOR-126876 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-251433 |
| PRKG2 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-276286 |
| INSR | phosphorylation → up-regulates | PTPN6 | SIGNOR-26870 |
| ABL1 | phosphorylation → unknown | PTPN6 | SIGNOR-246240 |
| PRKCQ | phosphorylation → down-regulates activity | PTPN6 | SIGNOR-277590 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | PTPN6 | SIGNOR-279147 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-260821 |
| PRKG2 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-276287 |
| PRKG2 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-276288 |
| LYN | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-251409 |
| LCK | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-251387 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-260820 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-246236 |
| SRC | phosphorylation → up-regulates | PTPN6 | SIGNOR-120488 |
| FYN | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-279716 |
| SRC | phosphorylation → up-regulates | PTPN6 | SIGNOR-120492 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-246227 |