| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates | 14699166 | SIGNOR-120488 |
| ABL1 | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 8692915 | SIGNOR-260820 |
| ABL1 | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 8692915 | SIGNOR-246227 |
| LCK | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 8114715 | SIGNOR-251387 |
| ABL1 | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates activity | 12468540 | SIGNOR-246236 |
| INSR | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates | 7512963 | SIGNOR-26870 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 14699166 | SIGNOR-120488 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-260820 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-246227 |
| LCK | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 8114715 | SIGNOR-251387 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 12468540 | SIGNOR-246236 |
| INSR | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 7512963 | SIGNOR-26870 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates | PTPN6 | SIGNOR-120488 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-260820 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-246227 |
| LCK | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-251387 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-246236 |
| INSR | phosphorylation → up-regulates | PTPN6 | SIGNOR-26870 |
