| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates | 8114715 | SIGNOR-36121 |
| LYN | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates activity | 10574931 | SIGNOR-251409 |
| SRC | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates | 14699166 | SIGNOR-120492 |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation unknown | 12468540 | SIGNOR-246240 |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates activity | 8692915 | SIGNOR-260821 |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation unknown | 8692915 | SIGNOR-246231 |
| ABL1 | PTPN6 | Tyr564 | SKHKEDVyENLHTKN | phosphorylation up-regulates activity | 8692915 | SIGNOR-251433 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 8114715 | SIGNOR-36121 |
| LYN | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 10574931 | SIGNOR-251409 |
| SRC | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 14699166 | SIGNOR-120492 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation down-regulates ⊣ | PTPN6 | 12468540 | SIGNOR-246240 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-260821 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation down-regulates ⊣ | PTPN6 | 8692915 | SIGNOR-246231 |
| ABL1 | phosphorylation up-regulates → | PTPN6 PTyr564 | phosphorylation up-regulates → | PTPN6 | 8692915 | SIGNOR-251433 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates | PTPN6 | SIGNOR-36121 |
| LYN | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-251409 |
| SRC | phosphorylation → up-regulates | PTPN6 | SIGNOR-120492 |
| ABL1 | phosphorylation → unknown | PTPN6 | SIGNOR-246240 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-260821 |
| ABL1 | phosphorylation → unknown | PTPN6 | SIGNOR-246231 |
| ABL1 | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-251433 |
