| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | PTPN6 | Ser591 | DKEKSKGsLKRK | phosphorylation down-regulates | 15269224 | SIGNOR-126876 |
| FYN | PTPN6 | Ser591 | DKEKSKGsLKRK | phosphorylation up-regulates activity | 28811476 | SIGNOR-279716 |
| PRKCQ | PTPN6 | Ser591 | DKEKSKGsLKRK | phosphorylation down-regulates activity | 35258455 | SIGNOR-277590 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | PTPN6 PSer591 | phosphorylation down-regulates ⊣ | PTPN6 | 15269224 | SIGNOR-126876 |
| FYN | phosphorylation up-regulates → | PTPN6 PSer591 | phosphorylation up-regulates → | PTPN6 | 28811476 | SIGNOR-279716 |
| PRKCQ | phosphorylation up-regulates → | PTPN6 PSer591 | phosphorylation down-regulates ⊣ | PTPN6 | 35258455 | SIGNOR-277590 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | PTPN6 | SIGNOR-126876 |
| FYN | phosphorylation → up-regulates activity | PTPN6 | SIGNOR-279716 |
| PRKCQ | phosphorylation → down-regulates activity | PTPN6 | SIGNOR-277590 |
