| Name | NOS3 |
| ID | P29474 |
| Role | substrate |
| Enzymatic Domains |
Flavodoxin-like 520-703 PROSITE-ProRule
FAD-binding FR-type 756-1002 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EPHB4 | NOS3 | – | phosphorylation up-regulates activity | 26817610 | SIGNOR-279172 | |
| PPP1CA | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248558 |
| PKC | NOS3 | – | phosphorylation down-regulates activity | 24379783 | SIGNOR-269971 | |
| PRKACA | NOS3 | Ser633 | WRRKRKEsSNTDSAG | phosphorylation up-regulates activity | 24379783 | SIGNOR-251616 |
| PPP1CB | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248574 |
| PRKCA | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251620 |
| PRKCE | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251632 |
| PRKCZ | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251637 |
| PRKACA | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112371 |
| AMPK | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 18303014 | SIGNOR-216627 |
| PRKAA1 | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation up-regulates activity | 24379783 | SIGNOR-251619 |
| PRKAA1 | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 18303014 | SIGNOR-160838 |
| AKT | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251628 |
| SRC | NOS3 | Tyr81 | WEVGSITyDTLSAQA | phosphorylation up-regulates activity | 32653904 | SIGNOR-277520 |
| PTPRB | NOS3 | Tyr81 | WEVGSITyDTLSAQA | dephosphorylation down-regulates activity | 32653904 | SIGNOR-277041 |
| AMPK | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251618 |
| PTK2B | NOS3 | Tyr657 | FGLGSRAyPHFCAFA | phosphorylation down-regulates | 18483407 | SIGNOR-178648 |
| PRKAB1 | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112367 |
| PRKACG | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112375 |
| PPP1CC | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248501 |
| PRKCQ | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251636 |
| AKT1 | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112363 |
| ABL1 | NOS3 | Tyr81 | WEVGSITyDTLSAQA | phosphorylation up-regulates activity | 32653904 | SIGNOR-277519 |
| PRKCG | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251633 |
| AKT2 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251624 |
| PTPRB | NOS3 | Tyr81 | WEVGSITyDTLSAQA | dephosphorylation down-regulates activity | 32653904 | SIGNOR-277521 |
| AKT1 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251622 |
| PRKCD | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251631 |
| CDK5 | NOS3 | Ser114 | RKLQGRPsPGPPAPE | phosphorylation down-regulates | 20213743 | SIGNOR-164080 |
| PRKACA | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251617 |
| PP1 | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-264668 |
| AKT | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-244322 |
| AKT3 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251626 |
| AMPK | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-216445 |
| PRKCB | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251630 |
| PRKCI | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251635 |
| PRKCH | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251634 |
| PTK2B | NOS3 | Tyr657 | FGLGSRAyPHFCAFA | phosphorylation down-regulates | 19934023 | SIGNOR-161824 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248558 |
| PRKACA | phosphorylation up-regulates → | NOS3 PSer633 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251616 |
| PPP1CB | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248574 |
| PRKCA | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251620 |
| PRKCE | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251632 |
| PRKCZ | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251637 |
| PRKACA | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112371 |
| AMPK | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 18303014 | SIGNOR-216627 |
| PRKAA1 | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251619 |
| PRKAA1 | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 18303014 | SIGNOR-160838 |
| AKT | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251628 |
| SRC | phosphorylation up-regulates → | NOS3 PTyr81 | phosphorylation up-regulates → | NOS3 | 32653904 | SIGNOR-277520 |
| PTPRB | dephosphorylation down-regulates ⊣ | NOS3 PTyr81 | dephosphorylation up-regulates → | NOS3 | 32653904 | SIGNOR-277041 |
| AMPK | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251618 |
| PTK2B | phosphorylation up-regulates → | NOS3 PTyr657 | phosphorylation down-regulates ⊣ | NOS3 | 18483407 | SIGNOR-178648 |
| PRKAB1 | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112367 |
| PRKACG | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112375 |
| PPP1CC | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248501 |
| PRKCQ | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251636 |
| AKT1 | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112363 |
| ABL1 | phosphorylation up-regulates → | NOS3 PTyr81 | phosphorylation up-regulates → | NOS3 | 32653904 | SIGNOR-277519 |
| PRKCG | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251633 |
| AKT2 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251624 |
| PTPRB | dephosphorylation down-regulates ⊣ | NOS3 PTyr81 | dephosphorylation up-regulates → | NOS3 | 32653904 | SIGNOR-277521 |
| AKT1 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251622 |
| PRKCD | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251631 |
| CDK5 | phosphorylation up-regulates → | NOS3 PSer114 | phosphorylation down-regulates ⊣ | NOS3 | 20213743 | SIGNOR-164080 |
| PRKACA | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251617 |
| PP1 | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-264668 |
| AKT | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-244322 |
| AKT3 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251626 |
| AMPK | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-216445 |
| PRKCB | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251630 |
| PRKCI | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251635 |
| PRKCH | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251634 |
| PTK2B | phosphorylation up-regulates → | NOS3 PTyr657 | phosphorylation down-regulates ⊣ | NOS3 | 19934023 | SIGNOR-161824 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EPHB4 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-279172 |
| PPP1CA | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248558 |
| PKC | phosphorylation → down-regulates activity | NOS3 | SIGNOR-269971 |
| PRKACA | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251616 |
| PPP1CB | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248574 |
| PRKCA | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251620 |
| PRKCE | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251632 |
| PRKCZ | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251637 |
| PRKACA | phosphorylation → up-regulates | NOS3 | SIGNOR-112371 |
| AMPK | phosphorylation → up-regulates | NOS3 | SIGNOR-216627 |
| PRKAA1 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251619 |
| PRKAA1 | phosphorylation → up-regulates | NOS3 | SIGNOR-160838 |
| AKT | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251628 |
| SRC | phosphorylation → up-regulates activity | NOS3 | SIGNOR-277520 |
| PTPRB | dephosphorylation → down-regulates activity | NOS3 | SIGNOR-277041 |
| AMPK | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251618 |
| PTK2B | phosphorylation down-regulates | NOS3 | SIGNOR-178648 |
| PRKAB1 | phosphorylation → up-regulates | NOS3 | SIGNOR-112367 |
| PRKACG | phosphorylation → up-regulates | NOS3 | SIGNOR-112375 |
| PPP1CC | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248501 |
| PRKCQ | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251636 |
| AKT1 | phosphorylation → up-regulates | NOS3 | SIGNOR-112363 |
| ABL1 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-277519 |
| PRKCG | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251633 |
| AKT2 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251624 |
| PTPRB | dephosphorylation → down-regulates activity | NOS3 | SIGNOR-277521 |
| AKT1 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251622 |
| PRKCD | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251631 |
| CDK5 | phosphorylation down-regulates | NOS3 | SIGNOR-164080 |
| PRKACA | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251617 |
| PP1 | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-264668 |
| AKT | phosphorylation → up-regulates | NOS3 | SIGNOR-244322 |
| AKT3 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251626 |
| AMPK | phosphorylation → up-regulates | NOS3 | SIGNOR-216445 |
| PRKCB | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251630 |
| PRKCI | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251635 |
| PRKCH | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251634 |
| PTK2B | phosphorylation down-regulates | NOS3 | SIGNOR-161824 |