| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2B | NOS3 | Tyr657 | FGLGSRAyPHFCAFA | phosphorylation down-regulates | 18483407 | SIGNOR-178648 |
| PTK2B | NOS3 | Tyr657 | FGLGSRAyPHFCAFA | phosphorylation down-regulates | 19934023 | SIGNOR-161824 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2B | phosphorylation up-regulates → | NOS3 PTyr657 | phosphorylation down-regulates ⊣ | NOS3 | 18483407 | SIGNOR-178648 |
| PTK2B | phosphorylation up-regulates → | NOS3 PTyr657 | phosphorylation down-regulates ⊣ | NOS3 | 19934023 | SIGNOR-161824 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2B | phosphorylation![]() down-regulates | NOS3 | SIGNOR-178648 |
| PTK2B | phosphorylation![]() down-regulates | NOS3 | SIGNOR-161824 |