| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-244322 |
| PRKACG | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112375 |
| AMPK | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 18303014 | SIGNOR-216627 |
| PRKACA | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112371 |
| AKT1 | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112363 |
| AMPK | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-216445 |
| PRKAB1 | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112367 |
| PRKAA1 | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 18303014 | SIGNOR-160838 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-244322 |
| PRKACG | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112375 |
| AMPK | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 18303014 | SIGNOR-216627 |
| PRKACA | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112371 |
| AKT1 | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112363 |
| AMPK | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-216445 |
| PRKAB1 | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112367 |
| PRKAA1 | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 18303014 | SIGNOR-160838 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates | NOS3 | SIGNOR-244322 |
| PRKACG | phosphorylation → up-regulates | NOS3 | SIGNOR-112375 |
| AMPK | phosphorylation → up-regulates | NOS3 | SIGNOR-216627 |
| PRKACA | phosphorylation → up-regulates | NOS3 | SIGNOR-112371 |
| AKT1 | phosphorylation → up-regulates | NOS3 | SIGNOR-112363 |
| AMPK | phosphorylation → up-regulates | NOS3 | SIGNOR-216445 |
| PRKAB1 | phosphorylation → up-regulates | NOS3 | SIGNOR-112367 |
| PRKAA1 | phosphorylation → up-regulates | NOS3 | SIGNOR-160838 |
