| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251628 |
| AKT3 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251626 |
| AKT2 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251624 |
| AKT1 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251622 |
| PRKACA | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251617 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251628 |
| AKT3 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251626 |
| AKT2 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251624 |
| AKT1 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251622 |
| PRKACA | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251617 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251628 |
| AKT3 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251626 |
| AKT2 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251624 |
| AKT1 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251622 |
| PRKACA | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251617 |