| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP1 | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-264668 |
| PRKCB | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251630 |
| PRKCI | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251635 |
| PRKCH | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251634 |
| PPP1CA | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248558 |
| PPP1CB | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248574 |
| PRKCE | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251632 |
| PRKCZ | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251637 |
| PRKCA | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251620 |
| PRKAA1 | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation up-regulates activity | 24379783 | SIGNOR-251619 |
| AMPK | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251618 |
| PPP1CC | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248501 |
| PRKCQ | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251636 |
| PRKCG | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251633 |
| PRKCD | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251631 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP1 | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-264668 |
| PRKCB | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251630 |
| PRKCI | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251635 |
| PRKCH | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251634 |
| PPP1CA | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248558 |
| PPP1CB | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248574 |
| PRKCE | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251632 |
| PRKCZ | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251637 |
| PRKCA | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251620 |
| PRKAA1 | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251619 |
| AMPK | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251618 |
| PPP1CC | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248501 |
| PRKCQ | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251636 |
| PRKCG | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251633 |
| PRKCD | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251631 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PP1 | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-264668 |
| PRKCB | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251630 |
| PRKCI | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251635 |
| PRKCH | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251634 |
| PPP1CA | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248558 |
| PPP1CB | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248574 |
| PRKCE | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251632 |
| PRKCZ | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251637 |
| PRKCA | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251620 |
| PRKAA1 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251619 |
| AMPK | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251618 |
| PPP1CC | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248501 |
| PRKCQ | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251636 |
| PRKCG | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251633 |
| PRKCD | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251631 |
