| Name | NOS1 |
| ID | P29475 |
| Role | substrate |
| Enzymatic Domains |
PDZ 17-99 PROSITE-ProRule
Flavodoxin-like 760-940 PROSITE-ProRule
FAD-binding FR-type 995-1242 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | NOS1 | – | phosphorylation unknown | 1375933 | SIGNOR-250021 | |
| PRKD1 | NOS1 | Ser1417 | TNRLRSEsIAFIEES | phosphorylation up-regulates activity | 24740233 | SIGNOR-278426 |
| CAMK1 | NOS1 | Ser852 | SYKVRFNsVSSYSDS | phosphorylation down-regulates activity | 10400690 | SIGNOR-250614 |
| CAMK2A | NOS1 | Ser852 | SYKVRFNsVSSYSDS | phosphorylation down-regulates activity | 10400690 | SIGNOR-250635 |
| CAMK4 | NOS1 | Ser852 | SYKVRFNsVSSYSDS | phosphorylation down-regulates activity | 10400690 | SIGNOR-250713 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD1 | phosphorylation up-regulates → | NOS1 PSer1417 | phosphorylation up-regulates → | NOS1 | 24740233 | SIGNOR-278426 |
| CAMK1 | phosphorylation up-regulates → | NOS1 PSer852 | phosphorylation down-regulates ⊣ | NOS1 | 10400690 | SIGNOR-250614 |
| CAMK2A | phosphorylation up-regulates → | NOS1 PSer852 | phosphorylation down-regulates ⊣ | NOS1 | 10400690 | SIGNOR-250635 |
| CAMK4 | phosphorylation up-regulates → | NOS1 PSer852 | phosphorylation down-regulates ⊣ | NOS1 | 10400690 | SIGNOR-250713 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → unknown | NOS1 | SIGNOR-250021 |
| PRKD1 | phosphorylation → up-regulates activity | NOS1 | SIGNOR-278426 |
| CAMK1 | phosphorylation → down-regulates activity | NOS1 | SIGNOR-250614 |
| CAMK2A | phosphorylation → down-regulates activity | NOS1 | SIGNOR-250635 |
| CAMK4 | phosphorylation → down-regulates activity | NOS1 | SIGNOR-250713 |