| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | NOS1 | Ser852 | SYKVRFNsVSSYSDS | phosphorylation down-regulates activity | 10400690 | SIGNOR-250614 |
| CAMK2A | NOS1 | Ser852 | SYKVRFNsVSSYSDS | phosphorylation down-regulates activity | 10400690 | SIGNOR-250635 |
| CAMK4 | NOS1 | Ser852 | SYKVRFNsVSSYSDS | phosphorylation down-regulates activity | 10400690 | SIGNOR-250713 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | phosphorylation up-regulates → | NOS1 PSer852 | phosphorylation down-regulates ⊣ | NOS1 | 10400690 | SIGNOR-250614 |
| CAMK2A | phosphorylation up-regulates → | NOS1 PSer852 | phosphorylation down-regulates ⊣ | NOS1 | 10400690 | SIGNOR-250635 |
| CAMK4 | phosphorylation up-regulates → | NOS1 PSer852 | phosphorylation down-regulates ⊣ | NOS1 | 10400690 | SIGNOR-250713 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK1 | phosphorylation → down-regulates activity | NOS1 | SIGNOR-250614 |
| CAMK2A | phosphorylation → down-regulates activity | NOS1 | SIGNOR-250635 |
| CAMK4 | phosphorylation → down-regulates activity | NOS1 | SIGNOR-250713 |