| Name | TYK2 |
| ID | P29597 |
| Role | kinase |
| Enzymatic Domains |
FERM 26-431 PROSITE-ProRule
SH2; atypical 450-529
Protein kinase 1 589-875 PROSITE-ProRule
Protein kinase 2 897-1176 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TYK2 | IFNAR1 | Tyr481 | PSSSIDEyFSEQPLK | phosphorylation up-regulates activity | 7526154 | SIGNOR-246939 |
| TYK2 | IFNAR1 | Tyr466 | VFLRCINyVFFPSLK | phosphorylation up-regulates activity | 8605876 | SIGNOR-246934 |
| TYK2 | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | phosphorylation up-regulates activity | 8702790 | SIGNOR-43088 |
| TYK2 | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | phosphorylation up-regulates activity | 8702790 | SIGNOR-43092 |
| TYK2 | STAT3 | – | phosphorylation up-regulates | 10542297 | SIGNOR-71781 | |
| TYK2 | STAT3 | – | phosphorylation up-regulates | 30029643 | SIGNOR-256255 | |
| TYK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 7657660 | SIGNOR-246943 |
| TYK2 | DUSP3 | Tyr138 | SPTLVIAyLMMRQKM | phosphorylation up-regulates | 17785772 | SIGNOR-157655 |
| TYK2 | STAT2 | – | phosphorylation up-regulates activity | 27782195 | SIGNOR-279133 | |
| TYK2 | KLF10 | – | phosphorylation down-regulates activity | 21471442 | SIGNOR-279575 | |
| TYK2 | STAT4 | Tyr693 | TERGDKGyVPSVFIP | phosphorylation up-regulates activity | 16324152 | SIGNOR-279303 |
| TYK2 | ISGF3 complex | – | phosphorylation up-regulates activity | 15120645 | SIGNOR-260148 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TYK2 | phosphorylation up-regulates → | IFNAR1 PTyr481 | phosphorylation up-regulates → | IFNAR1 | 7526154 | SIGNOR-246939 |
| TYK2 | phosphorylation up-regulates → | IFNAR1 PTyr466 | phosphorylation up-regulates → | IFNAR1 | 8605876 | SIGNOR-246934 |
| TYK2 | phosphorylation up-regulates → | TYK2 PTyr1054 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43088 |
| TYK2 | phosphorylation up-regulates → | TYK2 PTyr1055 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43092 |
| TYK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 7657660 | SIGNOR-246943 |
| TYK2 | phosphorylation up-regulates → | DUSP3 PTyr138 | phosphorylation up-regulates → | DUSP3 | 17785772 | SIGNOR-157655 |
| TYK2 | phosphorylation up-regulates → | STAT4 PTyr693 | phosphorylation up-regulates → | STAT4 | 16324152 | SIGNOR-279303 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TYK2 | phosphorylation → up-regulates activity | IFNAR1 | SIGNOR-246939 |
| TYK2 | phosphorylation → up-regulates activity | IFNAR1 | SIGNOR-246934 |
| TYK2 | phosphorylation → up-regulates activity | TYK2 | SIGNOR-43088 |
| TYK2 | phosphorylation → up-regulates activity | TYK2 | SIGNOR-43092 |
| TYK2 | phosphorylation → up-regulates | STAT3 | SIGNOR-71781 |
| TYK2 | phosphorylation → up-regulates | STAT3 | SIGNOR-256255 |
| TYK2 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-246943 |
| TYK2 | phosphorylation → up-regulates | DUSP3 | SIGNOR-157655 |
| TYK2 | phosphorylation → up-regulates activity | STAT2 | SIGNOR-279133 |
| TYK2 | phosphorylation → down-regulates activity | KLF10 | SIGNOR-279575 |
| TYK2 | phosphorylation → up-regulates activity | STAT4 | SIGNOR-279303 |
| TYK2 | phosphorylation → up-regulates activity | ISGF3 complex | SIGNOR-260148 |