| Name | TYK2 |
| ID | P29597 |
| Role | substrate |
| Enzymatic Domains |
FERM 26-431 PROSITE-ProRule
SH2; atypical 450-529
Protein kinase 1 589-875 PROSITE-ProRule
Protein kinase 2 897-1176 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TYK2 | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | phosphorylation up-regulates activity | 8702790 | SIGNOR-43088 |
| TYK2 | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | phosphorylation up-regulates activity | 8702790 | SIGNOR-43092 |
| PTPN1 | TYK2 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-134564 | |
| JAK1 | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | phosphorylation up-regulates | 8702790 | SIGNOR-43080 |
| JAK1 | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | phosphorylation up-regulates | 30029643 | SIGNOR-256221 |
| PTPRC | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248357 |
| JAK1 | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | phosphorylation up-regulates | 8702790 | SIGNOR-43084 |
| PTPRC | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248358 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TYK2 | phosphorylation up-regulates → | TYK2 PTyr1054 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43088 |
| TYK2 | phosphorylation up-regulates → | TYK2 PTyr1055 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43092 |
| JAK1 | phosphorylation up-regulates → | TYK2 PTyr1054 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43080 |
| JAK1 | phosphorylation up-regulates → | TYK2 PTyr1054 | phosphorylation up-regulates → | TYK2 | 30029643 | SIGNOR-256221 |
| PTPRC | dephosphorylation down-regulates ⊣ | TYK2 PTyr1054 | dephosphorylation up-regulates → | TYK2 | 11201744 | SIGNOR-248357 |
| JAK1 | phosphorylation up-regulates → | TYK2 PTyr1055 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43084 |
| PTPRC | dephosphorylation down-regulates ⊣ | TYK2 PTyr1055 | dephosphorylation up-regulates → | TYK2 | 11201744 | SIGNOR-248358 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TYK2 | phosphorylation → up-regulates activity | TYK2 | SIGNOR-43088 |
| TYK2 | phosphorylation → up-regulates activity | TYK2 | SIGNOR-43092 |
| PTPN1 | dephosphorylation → down-regulates activity | TYK2 | SIGNOR-134564 |
| JAK1 | phosphorylation → up-regulates | TYK2 | SIGNOR-43080 |
| JAK1 | phosphorylation → up-regulates | TYK2 | SIGNOR-256221 |
| PTPRC | dephosphorylation → down-regulates activity | TYK2 | SIGNOR-248357 |
| JAK1 | phosphorylation → up-regulates | TYK2 | SIGNOR-43084 |
| PTPRC | dephosphorylation → down-regulates activity | TYK2 | SIGNOR-248358 |