| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248358 |
| TYK2 | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | phosphorylation up-regulates activity | 8702790 | SIGNOR-43092 |
| JAK1 | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | phosphorylation up-regulates | 8702790 | SIGNOR-43084 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | dephosphorylation down-regulates ⊣ | TYK2 PTyr1055 | dephosphorylation up-regulates → | TYK2 | 11201744 | SIGNOR-248358 |
| TYK2 | phosphorylation up-regulates → | TYK2 PTyr1055 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43092 |
| JAK1 | phosphorylation up-regulates → | TYK2 PTyr1055 | phosphorylation up-regulates → | TYK2 | 8702790 | SIGNOR-43084 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRC | dephosphorylation → down-regulates activity | TYK2 | SIGNOR-248358 |
| TYK2 | phosphorylation → up-regulates activity | TYK2 | SIGNOR-43092 |
| JAK1 | phosphorylation → up-regulates | TYK2 | SIGNOR-43084 |
