| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK3 | PDHA2 | Ser291 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 16436377 | SIGNOR-143974 |
| PDK4 | PDHA2 | Ser291 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 14966024 | SIGNOR-121936 |
| PDK2 | PDHA2 | Ser291 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 16436377 | SIGNOR-143970 |
| PDK1 | PDHA2 | Ser291 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 16436377 | SIGNOR-143966 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK3 | phosphorylation up-regulates → | PDHA2 PSer291 | phosphorylation down-regulates ⊣ | PDHA2 | 16436377 | SIGNOR-143974 |
| PDK4 | phosphorylation up-regulates → | PDHA2 PSer291 | phosphorylation down-regulates ⊣ | PDHA2 | 14966024 | SIGNOR-121936 |
| PDK2 | phosphorylation up-regulates → | PDHA2 PSer291 | phosphorylation down-regulates ⊣ | PDHA2 | 16436377 | SIGNOR-143970 |
| PDK1 | phosphorylation up-regulates → | PDHA2 PSer291 | phosphorylation down-regulates ⊣ | PDHA2 | 16436377 | SIGNOR-143966 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDK3 | phosphorylation down-regulates | PDHA2 | SIGNOR-143974 |
| PDK4 | phosphorylation down-regulates | PDHA2 | SIGNOR-121936 |
| PDK2 | phosphorylation down-regulates | PDHA2 | SIGNOR-143970 |
| PDK1 | phosphorylation down-regulates | PDHA2 | SIGNOR-143966 |
