| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CCND3 | Thr283 | QGPSQTStPTDVTAI | phosphorylation down-regulates | 16331257 | SIGNOR-142880 |
| MAPK11 | CCND3 | Thr283 | QGPSQTStPTDVTAI | phosphorylation down-regulates quantity by destabilization | 15326477 | SIGNOR-280023 |
| ROBO | CCND3 | Thr283 | QGPSQTStPTDVTAI | phosphorylation down-regulates | 15326477 | SIGNOR-128402 |
| PPP1CA | CCND3 | Thr283 | QGPSQTStPTDVTAI | dephosphorylation up-regulates | 16331257 | SIGNOR-142884 |
| PP1 | CCND3 | Thr283 | QGPSQTStPTDVTAI | dephosphorylation up-regulates | 16331257 | SIGNOR-264662 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CCND3 PThr283 | phosphorylation down-regulates ⊣ | CCND3 | 16331257 | SIGNOR-142880 |
| MAPK11 | phosphorylation up-regulates → | CCND3 PThr283 | phosphorylation down-regulates ⊣ | CCND3 | 15326477 | SIGNOR-280023 |
| ROBO | phosphorylation up-regulates → | CCND3 PThr283 | phosphorylation down-regulates ⊣ | CCND3 | 15326477 | SIGNOR-128402 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CCND3 PThr283 | dephosphorylation down-regulates ⊣ | CCND3 | 16331257 | SIGNOR-142884 |
| PP1 | dephosphorylation down-regulates ⊣ | CCND3 PThr283 | dephosphorylation down-regulates ⊣ | CCND3 | 16331257 | SIGNOR-264662 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates | CCND3 | SIGNOR-142880 |
| MAPK11 | phosphorylation down-regulates quantity by destabilization | CCND3 | SIGNOR-280023 |
| ROBO | phosphorylation down-regulates | CCND3 | SIGNOR-128402 |
| PPP1CA | dephosphorylation → up-regulates | CCND3 | SIGNOR-142884 |
| PP1 | dephosphorylation → up-regulates | CCND3 | SIGNOR-264662 |
