Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
WEE1	PLRG1	–		phosphorylation down-regulates activity	33450002	SIGNOR-279579
WEE1	CDK1	Tyr15	EKIGEGTyGVVYKGR	phosphorylation down-regulates	16096060	SIGNOR-139491
WEE1	ERG	Tyr183	FQRLTPSyNADILLS	phosphorylation down-regulates quantity by destabilization	32871104	SIGNOR-277529
WEE1	CDK2	Tyr15	EKIGEGTyGVVYKAR	phosphorylation down-regulates	11029659	SIGNOR-83139
WEE1	PTP4A1	–		phosphorylation down-regulates activity	33450002	SIGNOR-278434

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
WEE1	phosphorylation up-regulates →	CDK1 PTyr15	phosphorylation down-regulates ⊣	CDK1	16096060	SIGNOR-139491
WEE1	phosphorylation up-regulates →	ERG PTyr183	phosphorylation down-regulates ⊣	ERG	32871104	SIGNOR-277529
WEE1	phosphorylation up-regulates →	CDK2 PTyr15	phosphorylation down-regulates ⊣	CDK2	11029659	SIGNOR-83139

Regulator	Mechanism/Effect	Target	SIGNOR-ID
WEE1	phosphorylation → down-regulates activity	PLRG1	SIGNOR-279579
WEE1	phosphorylation down-regulates	CDK1	SIGNOR-139491
WEE1	phosphorylation down-regulates quantity by destabilization	ERG	SIGNOR-277529
WEE1	phosphorylation down-regulates	CDK2	SIGNOR-83139
WEE1	phosphorylation → down-regulates activity	PTP4A1	SIGNOR-278434