| Name | WEE1 |
| ID | P30291 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 299-569 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 16085715 | SIGNOR-139469 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 15350223 | SIGNOR-128643 |
| CyclinB/CDK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates quantity by destabilization | 23051732 | SIGNOR-267471 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates quantity by destabilization | 16085715 | SIGNOR-276040 |
| PAK1 | WEE1 | – | phosphorylation down-regulates | 15037762 | SIGNOR-123528 | |
| BRSK1 | WEE1 | Ser642 | KKMNRSVsLTIY | phosphorylation unknown | 15150265 | SIGNOR-250601 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 16085715 | SIGNOR-139477 |
| CDC14A | WEE1 | Ser139 | YFLGSSFsPVRCGGP | dephosphorylation up-regulates quantity by stabilization | 23051732 | SIGNOR-267470 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 15070733 | SIGNOR-123832 |
| CDC14A | WEE1 | Ser139 | YFLGSSFsPVRCGGP | dephosphorylation up-regulates quantity by stabilization | 23051732 | SIGNOR-276953 |
| CHEK1 | WEE1 | – | phosphorylation up-regulates | 20068082 | SIGNOR-163164 | |
| GSK3B | WEE1 | Ser211 | SSVKLRGsSLFMDTE | phosphorylation down-regulates quantity by destabilization | 24817118 | SIGNOR-276632 |
| CDC14A | WEE1 | Ser123 | EEGFGSSsPVKSPAA | dephosphorylation up-regulates quantity by stabilization | 23051732 | SIGNOR-276952 |
| CDK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 15070733 | SIGNOR-123824 |
| CSNK1D | WEE1 | Ser212 | SVKLRGSsLFMDTEK | phosphorylation down-regulates quantity by destabilization | 24817118 | SIGNOR-276631 |
| PLK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 16085715 | SIGNOR-139473 |
| CSNK2A1 | WEE1 | Ser121 | WEEEGFGsSSPVKSP | phosphorylation down-regulates quantity by destabilization | 16085715 | SIGNOR-276038 |
| NIM1K | WEE1 | – | phosphorylation down-regulates activity | 8515817 | SIGNOR-279238 | |
| CHEK1 | WEE1 | Ser642 | KKMNRSVsLTIY | phosphorylation up-regulates activity | 28396830 | SIGNOR-279027 |
| CDC14A | WEE1 | Ser123 | EEGFGSSsPVKSPAA | dephosphorylation up-regulates quantity by stabilization | 23051732 | SIGNOR-267469 |
| CTDP1 | WEE1 | – | dephosphorylation up-regulates activity | 27670139 | SIGNOR-277142 | |
| CDK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 16085715 | SIGNOR-139465 |
| PPP2R2A | WEE1 | – | dephosphorylation up-regulates quantity by stabilization | 33108758 | SIGNOR-266381 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139469 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 15350223 | SIGNOR-128643 |
| CyclinB/CDK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-267471 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-276040 |
| BRSK1 | phosphorylation up-regulates → | WEE1 PSer642 | phosphorylation down-regulates ⊣ | WEE1 | 15150265 | SIGNOR-250601 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139477 |
| CDC14A | dephosphorylation down-regulates ⊣ | WEE1 PSer139 | dephosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-267470 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 15070733 | SIGNOR-123832 |
| CDC14A | dephosphorylation down-regulates ⊣ | WEE1 PSer139 | dephosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-276953 |
| GSK3B | phosphorylation up-regulates → | WEE1 PSer211 | phosphorylation down-regulates ⊣ | WEE1 | 24817118 | SIGNOR-276632 |
| CDC14A | dephosphorylation down-regulates ⊣ | WEE1 PSer123 | dephosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-276952 |
| CDK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 15070733 | SIGNOR-123824 |
| CSNK1D | phosphorylation up-regulates → | WEE1 PSer212 | phosphorylation down-regulates ⊣ | WEE1 | 24817118 | SIGNOR-276631 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139473 |
| CSNK2A1 | phosphorylation up-regulates → | WEE1 PSer121 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-276038 |
| CHEK1 | phosphorylation up-regulates → | WEE1 PSer642 | phosphorylation up-regulates → | WEE1 | 28396830 | SIGNOR-279027 |
| CDC14A | dephosphorylation down-regulates ⊣ | WEE1 PSer123 | dephosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-267469 |
| CDK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139465 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation down-regulates | WEE1 | SIGNOR-139469 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-128643 |
| CyclinB/CDK1 | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-267471 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-276040 |
| PAK1 | phosphorylation down-regulates | WEE1 | SIGNOR-123528 |
| BRSK1 | phosphorylation → unknown | WEE1 | SIGNOR-250601 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139477 |
| CDC14A | dephosphorylation → up-regulates quantity by stabilization | WEE1 | SIGNOR-267470 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-123832 |
| CDC14A | dephosphorylation → up-regulates quantity by stabilization | WEE1 | SIGNOR-276953 |
| CHEK1 | phosphorylation → up-regulates | WEE1 | SIGNOR-163164 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-276632 |
| CDC14A | dephosphorylation → up-regulates quantity by stabilization | WEE1 | SIGNOR-276952 |
| CDK1 | phosphorylation down-regulates | WEE1 | SIGNOR-123824 |
| CSNK1D | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-276631 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139473 |
| CSNK2A1 | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-276038 |
| NIM1K | phosphorylation → down-regulates activity | WEE1 | SIGNOR-279238 |
| CHEK1 | phosphorylation → up-regulates activity | WEE1 | SIGNOR-279027 |
| CDC14A | dephosphorylation → up-regulates quantity by stabilization | WEE1 | SIGNOR-267469 |
| CTDP1 | dephosphorylation → up-regulates activity | WEE1 | SIGNOR-277142 |
| CDK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139465 |
| PPP2R2A | dephosphorylation → up-regulates quantity by stabilization | WEE1 | SIGNOR-266381 |