| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC14A | WEE1 | Ser123 | EEGFGSSsPVKSPAA | dephosphorylation up-regulates quantity by stabilization | 23051732 | SIGNOR-267469 |
| CDK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 16085715 | SIGNOR-139465 |
| CDK2 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 16085715 | SIGNOR-139469 |
| CyclinB/CDK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates quantity by destabilization | 23051732 | SIGNOR-267471 |
| CDK2 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | down-regulates quantity by destabilization | 16085715 | SIGNOR-276039 |
| CDC14A | WEE1 | Ser123 | EEGFGSSsPVKSPAA | dephosphorylation up-regulates quantity by stabilization | 23051732 | SIGNOR-276952 |
| CDK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 15070733 | SIGNOR-123824 |
| PLK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 16085715 | SIGNOR-139473 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC14A | dephosphorylation down-regulates ⊣ | WEE1 PSer123 | dephosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-267469 |
| CDK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139465 |
| CDK2 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139469 |
| CyclinB/CDK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-267471 |
| CDK2 | up-regulates → | WEE1 PSer123 | down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-276039 |
| CDC14A | dephosphorylation down-regulates ⊣ | WEE1 PSer123 | dephosphorylation down-regulates ⊣ | WEE1 | 23051732 | SIGNOR-276952 |
| CDK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 15070733 | SIGNOR-123824 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139473 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC14A | dephosphorylation → up-regulates quantity by stabilization | WEE1 | SIGNOR-267469 |
| CDK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139465 |
| CDK2 | phosphorylation down-regulates | WEE1 | SIGNOR-139469 |
| CyclinB/CDK1 | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-267471 |
| CDK2 | down-regulates quantity by destabilization | WEE1 | SIGNOR-276039 |
| CDC14A | dephosphorylation → up-regulates quantity by stabilization | WEE1 | SIGNOR-276952 |
| CDK1 | phosphorylation down-regulates | WEE1 | SIGNOR-123824 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139473 |
