| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 15350223 | SIGNOR-128643 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates quantity by destabilization | 16085715 | SIGNOR-276040 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 16085715 | SIGNOR-139477 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 15070733 | SIGNOR-123832 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 15350223 | SIGNOR-128643 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-276040 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139477 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 15070733 | SIGNOR-123832 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-128643 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-276040 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139477 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-123832 |
