Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDC25A	RAF1	–		dephosphorylation down-regulates	7744247	SIGNOR-32548
CDC25A	CDK1	Thr14	IEKIGEGtYGVVYKG	dephosphorylation up-regulates activity	10454565	SIGNOR-248479
CDC25A	CDK1	Tyr15	EKIGEGTyGVVYKGR	dephosphorylation up-regulates activity	10454565	SIGNOR-248480
CDC25A	CDK4	Tyr17	AEIGVGAyGTVYKAR	dephosphorylation up-regulates activity	23429262	SIGNOR-267568
CDC25A	CDK4	Tyr17	AEIGVGAyGTVYKAR	dephosphorylation up-regulates activity	27485204	SIGNOR-277138
CDC25A	PKM	Ser37	MCRLDIDsPPITARN	dephosphorylation up-regulates activity	27485204	SIGNOR-276967
CDC25A	CCNB1	–		dephosphorylation up-regulates activity	16682204	SIGNOR-277137
CDC25A	CCNA2	–		dephosphorylation up-regulates activity	16682204	SIGNOR-277136
CDC25A	CDK2	Thr14	VEKIGEGtYGVVYKA	dephosphorylation up-regulates	12411508	SIGNOR-95252
CDC25A	CDK2	Thr14	VEKIGEGtYGVVYKA	dephosphorylation up-regulates	22263797	SIGNOR-195521
CDC25A	CDK2	Thr14	VEKIGEGtYGVVYKA	dephosphorylation up-regulates activity	10454565	SIGNOR-248481
CDC25A	CDK2	Tyr15	EKIGEGTyGVVYKAR	dephosphorylation up-regulates activity	10454565	SIGNOR-248482
CDC25A	CDK2	–		dephosphorylation up-regulates activity	11154267	SIGNOR-245449
CDC25A	MAPK3	–		dephosphorylation down-regulates	15672448	SIGNOR-133392
CDC25A	CDK6	Tyr24	AEIGEGAyGKVFKAR	dephosphorylation up-regulates activity	23429262	SIGNOR-267569
CDC25A	FOXO1	–		dephosphorylation up-regulates activity	21670150	SIGNOR-277139
CDC25A	DYRK2	–		dephosphorylation down-regulates activity	34363019	SIGNOR-277098
CDC25A	CyclinE/CDK2	–		dephosphorylation up-regulates activity	11154267	SIGNOR-245452
CDC25A	CyclinD/CDK4	–		dephosphorylation up-regulates activity	23429262	SIGNOR-245456

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDC25A	dephosphorylation down-regulates ⊣	CDK1 PThr14	dephosphorylation down-regulates ⊣	CDK1	10454565	SIGNOR-248479
CDC25A	dephosphorylation down-regulates ⊣	CDK1 PTyr15	dephosphorylation down-regulates ⊣	CDK1	10454565	SIGNOR-248480
CDC25A	dephosphorylation down-regulates ⊣	CDK4 PTyr17	dephosphorylation down-regulates ⊣	CDK4	23429262	SIGNOR-267568
CDC25A	dephosphorylation down-regulates ⊣	CDK4 PTyr17	dephosphorylation down-regulates ⊣	CDK4	27485204	SIGNOR-277138
CDC25A	dephosphorylation down-regulates ⊣	PKM PSer37	dephosphorylation down-regulates ⊣	PKM	27485204	SIGNOR-276967
CDC25A	dephosphorylation down-regulates ⊣	CDK2 PThr14	dephosphorylation down-regulates ⊣	CDK2	12411508	SIGNOR-95252
CDC25A	dephosphorylation down-regulates ⊣	CDK2 PThr14	dephosphorylation down-regulates ⊣	CDK2	22263797	SIGNOR-195521
CDC25A	dephosphorylation down-regulates ⊣	CDK2 PThr14	dephosphorylation down-regulates ⊣	CDK2	10454565	SIGNOR-248481
CDC25A	dephosphorylation down-regulates ⊣	CDK2 PTyr15	dephosphorylation down-regulates ⊣	CDK2	10454565	SIGNOR-248482
CDC25A	dephosphorylation down-regulates ⊣	CDK6 PTyr24	dephosphorylation down-regulates ⊣	CDK6	23429262	SIGNOR-267569

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDC25A	dephosphorylation down-regulates	RAF1	SIGNOR-32548
CDC25A	dephosphorylation → up-regulates activity	CDK1	SIGNOR-248479
CDC25A	dephosphorylation → up-regulates activity	CDK1	SIGNOR-248480
CDC25A	dephosphorylation → up-regulates activity	CDK4	SIGNOR-267568
CDC25A	dephosphorylation → up-regulates activity	CDK4	SIGNOR-277138
CDC25A	dephosphorylation → up-regulates activity	PKM	SIGNOR-276967
CDC25A	dephosphorylation → up-regulates activity	CCNB1	SIGNOR-277137
CDC25A	dephosphorylation → up-regulates activity	CCNA2	SIGNOR-277136
CDC25A	dephosphorylation → up-regulates	CDK2	SIGNOR-95252
CDC25A	dephosphorylation → up-regulates	CDK2	SIGNOR-195521
CDC25A	dephosphorylation → up-regulates activity	CDK2	SIGNOR-248481
CDC25A	dephosphorylation → up-regulates activity	CDK2	SIGNOR-248482
CDC25A	dephosphorylation → up-regulates activity	CDK2	SIGNOR-245449
CDC25A	dephosphorylation down-regulates	MAPK3	SIGNOR-133392
CDC25A	dephosphorylation → up-regulates activity	CDK6	SIGNOR-267569
CDC25A	dephosphorylation → up-regulates activity	FOXO1	SIGNOR-277139
CDC25A	dephosphorylation → down-regulates activity	DYRK2	SIGNOR-277098
CDC25A	dephosphorylation → up-regulates activity	CyclinE/CDK2	SIGNOR-245452
CDC25A	dephosphorylation → up-regulates activity	CyclinD/CDK4	SIGNOR-245456