| Name | CDC25A |
| ID | P30304 |
| Role | substrate |
| Enzymatic Domains |
Rhodanese 376-482 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | CDC25A | Ser185 | SAPARMLsSNERDSS | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276739 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99721 |
| CHEK2 | CDC25A | Ser279 | VLKRPERsQEESPPG | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260834 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260835 |
| DYRK2 | CDC25A | Ser18 | RRLLFACsPPPASQP | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276736 |
| CHEK1 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates | 20068082 | SIGNOR-163134 |
| CSNK1A1 | CDC25A | Ser82 | GSSESTDsGFCLDSP | phosphorylation down-regulates | 20348946 | SIGNOR-164738 |
| NEK11 | CDC25A | Ser82 | GSSESTDsGFCLDSP | phosphorylation down-regulates | 19734889 | SIGNOR-187867 |
| DYRK2 | CDC25A | Ser107 | NPMRRIHsLPQKLLG | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276738 |
| CyclinD3/CDK6 | CDC25A | Ser88 | DSGFCLDsPGPLDSK | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277341 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 11298456 | SIGNOR-260778 |
| DYRK2 | CDC25A | Ser156 | KKPVRPVsRGCLHSH | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276740 |
| CHEK2 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260833 |
| CDK2 | CDC25A | Ser263 | CKLFDSPsLCSSSTR | phosphorylation down-regulates | 17110335 | SIGNOR-150839 |
| RPS6KA1 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 23708659 | SIGNOR-202113 |
| RPS6K | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 23708659 | SIGNOR-252793 |
| RPS6K | CDC25A | Ser295 | TKRRKSMsGASPKES | phosphorylation down-regulates | 23708659 | SIGNOR-252776 |
| CHEK1 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 20068082 | SIGNOR-163146 |
| NEK11 | CDC25A | Ser88 | DSGFCLDsPGPLDSK | phosphorylation down-regulates | 19734889 | SIGNOR-187871 |
| CDC14A | CDC25A | – | dephosphorylation down-regulates activity | 20956543 | SIGNOR-277065 | |
| ATR | CDC25A | – | phosphorylation down-regulates activity | 29054375 | SIGNOR-280183 | |
| CSNK1A1 | CDC25A | Ser79 | QRMGSSEsTDSGFCL | phosphorylation down-regulates | 20348946 | SIGNOR-164734 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 11298456 | SIGNOR-106808 |
| CyclinB/CDK1 | CDC25A | Ser116 | PQKLLGCsPALKRSH | phosphorylation up-regulates | 12411508 | SIGNOR-216761 |
| DYRK2 | CDC25A | Ser320 | HQSLSLAsSPKGTIE | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276734 |
| RPS6KA1 | CDC25A | Ser295 | TKRRKSMsGASPKES | phosphorylation down-regulates | 23708659 | SIGNOR-202117 |
| CHEK2 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99725 |
| CyclinD/CDK4 | CDC25A | Ser88 | DSGFCLDsPGPLDSK | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277342 |
| GSK3B | CDC25A | Ser76 | SNLQRMGsSESTDSG | phosphorylation down-regulates quantity by repression | 20348946 | SIGNOR-164742 |
| CHEK1 | CDC25A | Ser279 | VLKRPERsQEESPPG | phosphorylation down-regulates | 20068082 | SIGNOR-163142 |
| CHEK2 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260836 |
| DYRK2 | CDC25A | Ser283 | PERSQEEsPPGSTKR | phosphorylation down-regulates quantity | 34363019 | SIGNOR-279367 |
| CHEK1 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates | 20068082 | SIGNOR-163138 |
| MAPKAPK2 | CDC25A | – | phosphorylation down-regulates | 17292828 | SIGNOR-152996 | |
| PLK3 | CDC25A | Thr80 | RMGSSEStDSGFCLD | phosphorylation down-regulates | 18167338 | SIGNOR-160228 |
| CyclinD3/CDK6 | CDC25A | Ser40 | ASAAGGLsPVTNLTV | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277343 |
| PIM2 | CDC25A | – | phosphorylation down-regulates quantity by destabilization | 22506047 | SIGNOR-279750 | |
| CHEK2 | CDC25A | Ser279 | VLKRPERsQEESPPG | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99729 |
| CyclinD/CDK4 | CDC25A | Ser40 | ASAAGGLsPVTNLTV | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277340 |
| DYRK2 | CDC25A | Ser88 | DSGFCLDsPGPLDSK | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276737 |
| CDK1 | CDC25A | Ser116 | PQKLLGCsPALKRSH | phosphorylation up-regulates | 12411508 | SIGNOR-95256 |
| CHEK1 | CDC25A | Ser76 | SNLQRMGsSESTDSG | phosphorylation down-regulates | 20068082 | SIGNOR-163150 |
| CHEK1 | CDC25A | Thr507 | KFRTKSRtWAGEKSK | phosphorylation down-regulates | 20068082 | SIGNOR-163154 |
| CHEK2 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates quantity by destabilization | 14559997 | SIGNOR-118759 |
| CHEK2 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99733 |
| STK38 | CDC25A | Ser76 | SNLQRMGsSESTDSG | phosphorylation down-regulates quantity | 25936524 | SIGNOR-279488 |
| CDK1 | CDC25A | Ser18 | RRLLFACsPPPASQP | phosphorylation up-regulates | 12411508 | SIGNOR-95260 |
| DYRK2 | CDC25A | Ser321 | QSLSLASsPKGTIEN | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276735 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer185 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276739 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99721 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer279 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260834 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260835 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer18 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276736 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163134 |
| CSNK1A1 | phosphorylation up-regulates → | CDC25A PSer82 | phosphorylation down-regulates ⊣ | CDC25A | 20348946 | SIGNOR-164738 |
| NEK11 | phosphorylation up-regulates → | CDC25A PSer82 | phosphorylation down-regulates ⊣ | CDC25A | 19734889 | SIGNOR-187867 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer107 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276738 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | CDC25A PSer88 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277341 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 11298456 | SIGNOR-260778 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer156 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276740 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260833 |
| CDK2 | phosphorylation up-regulates → | CDC25A PSer263 | phosphorylation down-regulates ⊣ | CDC25A | 17110335 | SIGNOR-150839 |
| RPS6KA1 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-202113 |
| RPS6K | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-252793 |
| RPS6K | phosphorylation up-regulates → | CDC25A PSer295 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-252776 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163146 |
| NEK11 | phosphorylation up-regulates → | CDC25A PSer88 | phosphorylation down-regulates ⊣ | CDC25A | 19734889 | SIGNOR-187871 |
| CSNK1A1 | phosphorylation up-regulates → | CDC25A PSer79 | phosphorylation down-regulates ⊣ | CDC25A | 20348946 | SIGNOR-164734 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 11298456 | SIGNOR-106808 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25A PSer116 | phosphorylation up-regulates → | CDC25A | 12411508 | SIGNOR-216761 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer320 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276734 |
| RPS6KA1 | phosphorylation up-regulates → | CDC25A PSer295 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-202117 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99725 |
| CyclinD/CDK4 | phosphorylation up-regulates → | CDC25A PSer88 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277342 |
| GSK3B | phosphorylation up-regulates → | CDC25A PSer76 | phosphorylation down-regulates ⊣ | CDC25A | 20348946 | SIGNOR-164742 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer279 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163142 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260836 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer283 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-279367 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163138 |
| PLK3 | phosphorylation up-regulates → | CDC25A PThr80 | phosphorylation down-regulates ⊣ | CDC25A | 18167338 | SIGNOR-160228 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | CDC25A PSer40 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277343 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer279 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99729 |
| CyclinD/CDK4 | phosphorylation up-regulates → | CDC25A PSer40 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277340 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer88 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276737 |
| CDK1 | phosphorylation up-regulates → | CDC25A PSer116 | phosphorylation up-regulates → | CDC25A | 12411508 | SIGNOR-95256 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer76 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163150 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PThr507 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163154 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 14559997 | SIGNOR-118759 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99733 |
| STK38 | phosphorylation up-regulates → | CDC25A PSer76 | phosphorylation down-regulates ⊣ | CDC25A | 25936524 | SIGNOR-279488 |
| CDK1 | phosphorylation up-regulates → | CDC25A PSer18 | phosphorylation up-regulates → | CDC25A | 12411508 | SIGNOR-95260 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer321 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276735 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276739 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99721 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260834 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260835 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276736 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163134 |
| CSNK1A1 | phosphorylation down-regulates | CDC25A | SIGNOR-164738 |
| NEK11 | phosphorylation down-regulates | CDC25A | SIGNOR-187867 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276738 |
| CyclinD3/CDK6 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277341 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-260778 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276740 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260833 |
| CDK2 | phosphorylation down-regulates | CDC25A | SIGNOR-150839 |
| RPS6KA1 | phosphorylation down-regulates | CDC25A | SIGNOR-202113 |
| RPS6K | phosphorylation down-regulates | CDC25A | SIGNOR-252793 |
| RPS6K | phosphorylation down-regulates | CDC25A | SIGNOR-252776 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163146 |
| NEK11 | phosphorylation down-regulates | CDC25A | SIGNOR-187871 |
| CDC14A | dephosphorylation → down-regulates activity | CDC25A | SIGNOR-277065 |
| ATR | phosphorylation → down-regulates activity | CDC25A | SIGNOR-280183 |
| CSNK1A1 | phosphorylation down-regulates | CDC25A | SIGNOR-164734 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-106808 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25A | SIGNOR-216761 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276734 |
| RPS6KA1 | phosphorylation down-regulates | CDC25A | SIGNOR-202117 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99725 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277342 |
| GSK3B | phosphorylation → down-regulates quantity by repression | CDC25A | SIGNOR-164742 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163142 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260836 |
| DYRK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-279367 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163138 |
| MAPKAPK2 | phosphorylation down-regulates | CDC25A | SIGNOR-152996 |
| PLK3 | phosphorylation down-regulates | CDC25A | SIGNOR-160228 |
| CyclinD3/CDK6 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277343 |
| PIM2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-279750 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99729 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277340 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276737 |
| CDK1 | phosphorylation → up-regulates | CDC25A | SIGNOR-95256 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163150 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163154 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-118759 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99733 |
| STK38 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-279488 |
| CDK1 | phosphorylation → up-regulates | CDC25A | SIGNOR-95260 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276735 |