| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99721 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260835 |
| CHEK1 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates | 20068082 | SIGNOR-163134 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 11298456 | SIGNOR-260778 |
| CHEK2 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates quantity by destabilization | 11298456 | SIGNOR-106808 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99721 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260835 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163134 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 11298456 | SIGNOR-260778 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 11298456 | SIGNOR-106808 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99721 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260835 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163134 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-260778 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-106808 |
