Entity Details

Name CHEK2_Ser178
ID P30304
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CHEK2CDC25ASer178LFTQRQNsAPARMLSphosphorylation
down-regulates quantity by destabilization		14559997SIGNOR-118759
CHEK2CDC25ASer178LFTQRQNsAPARMLSphosphorylation
down-regulates quantity		12676583SIGNOR-260833
CHEK1CDC25ASer178LFTQRQNsAPARMLSphosphorylation
down-regulates		20068082SIGNOR-163138
CHEK2CDC25ASer178LFTQRQNsAPARMLSphosphorylation
down-regulates quantity by destabilization		12676583SIGNOR-99725
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CHEK2phosphorylation
up-regulates
→
CDC25A
PSer178		phosphorylation
down-regulates
⊣		CDC25A14559997SIGNOR-118759
CHEK2phosphorylation
up-regulates
→
CDC25A
PSer178		phosphorylation
down-regulates
⊣		CDC25A12676583SIGNOR-260833
CHEK1phosphorylation
up-regulates
→
CDC25A
PSer178		phosphorylation
down-regulates
⊣		CDC25A20068082SIGNOR-163138
CHEK2phosphorylation
up-regulates
→
CDC25A
PSer178		phosphorylation
down-regulates
⊣		CDC25A12676583SIGNOR-99725
Regulator Mechanism/Effect Target SIGNOR-ID
CHEK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CDC25ASIGNOR-118759
CHEK2phosphorylation
→
down-regulates quantity 		CDC25ASIGNOR-260833
CHEK1phosphorylation
img/direct_inhibition.png
down-regulates 		CDC25ASIGNOR-163138
CHEK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CDC25ASIGNOR-99725