Entity Details

Name DYRK2_Ser88
ID P30304
Role residue
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinD/CDK4CDC25ASer88DSGFCLDsPGPLDSKphosphorylation
down-regulates quantity by destabilization		28192398SIGNOR-277342
DYRK2CDC25ASer88DSGFCLDsPGPLDSKphosphorylation
down-regulates quantity by destabilization		34363019SIGNOR-276737
CyclinD3/CDK6CDC25ASer88DSGFCLDsPGPLDSKphosphorylation
down-regulates quantity by destabilization		28192398SIGNOR-277341
NEK11CDC25ASer88DSGFCLDsPGPLDSKphosphorylation
down-regulates		19734889SIGNOR-187871
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinD/CDK4phosphorylation
up-regulates
→
CDC25A
PSer88		phosphorylation
down-regulates
⊣		CDC25A28192398SIGNOR-277342
DYRK2phosphorylation
up-regulates
→
CDC25A
PSer88		phosphorylation
down-regulates
⊣		CDC25A34363019SIGNOR-276737
CyclinD3/CDK6phosphorylation
up-regulates
→
CDC25A
PSer88		phosphorylation
down-regulates
⊣		CDC25A28192398SIGNOR-277341
NEK11phosphorylation
up-regulates
→
CDC25A
PSer88		phosphorylation
down-regulates
⊣		CDC25A19734889SIGNOR-187871
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinD/CDK4phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CDC25ASIGNOR-277342
DYRK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CDC25ASIGNOR-276737
CyclinD3/CDK6phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CDC25ASIGNOR-277341
NEK11phosphorylation
img/direct_inhibition.png
down-regulates 		CDC25ASIGNOR-187871