| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 23708659 | SIGNOR-202113 |
| RPS6K | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 23708659 | SIGNOR-252793 |
| CHEK1 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 20068082 | SIGNOR-163146 |
| CHEK2 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates quantity | 12676583 | SIGNOR-260836 |
| CHEK2 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates quantity by destabilization | 12676583 | SIGNOR-99733 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-202113 |
| RPS6K | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 23708659 | SIGNOR-252793 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163146 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-260836 |
| CHEK2 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 12676583 | SIGNOR-99733 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA1 | phosphorylation down-regulates | CDC25A | SIGNOR-202113 |
| RPS6K | phosphorylation down-regulates | CDC25A | SIGNOR-252793 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163146 |
| CHEK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-260836 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-99733 |
