| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CDC25A | Ser76 | SNLQRMGsSESTDSG | phosphorylation down-regulates quantity by repression | 20348946 | SIGNOR-164742 |
| CHEK1 | CDC25A | Ser76 | SNLQRMGsSESTDSG | phosphorylation down-regulates | 20068082 | SIGNOR-163150 |
| STK38 | CDC25A | Ser76 | SNLQRMGsSESTDSG | phosphorylation down-regulates quantity | 25936524 | SIGNOR-279488 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CDC25A PSer76 | phosphorylation down-regulates ⊣ | CDC25A | 20348946 | SIGNOR-164742 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer76 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163150 |
| STK38 | phosphorylation up-regulates → | CDC25A PSer76 | phosphorylation down-regulates ⊣ | CDC25A | 25936524 | SIGNOR-279488 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates quantity by repression | CDC25A | SIGNOR-164742 |
| CHEK1 | phosphorylation![]() down-regulates | CDC25A | SIGNOR-163150 |
| STK38 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-279488 |