Entity Details

Name CDC25B
ID P30305
Role phosphatase
Enzymatic Domains
Rhodanese 431-538
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDC25BCDK1–dephosphorylation
up-regulates		7880537SIGNOR-34541
CDC25BCDK1Thr14IEKIGEGtYGVVYKGdephosphorylation
up-regulates activity		25384584SIGNOR-276969
CDC25BCDK1Tyr15EKIGEGTyGVVYKGRdephosphorylation
up-regulates activity		25384584SIGNOR-276970
CDC25BCDK2–dephosphorylation
up-regulates activity		26474275SIGNOR-277140
CDC25BCyclinB/CDK1–dephosphorylation
up-regulates		7880537SIGNOR-217511
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDC25Bdephosphorylation
down-regulates
⊣
CDK1
PThr14		dephosphorylation
down-regulates
⊣		CDK125384584SIGNOR-276969
CDC25Bdephosphorylation
down-regulates
⊣
CDK1
PTyr15		dephosphorylation
down-regulates
⊣		CDK125384584SIGNOR-276970
Regulator Mechanism/Effect Target SIGNOR-ID
CDC25Bdephosphorylation
→
up-regulates 		CDK1SIGNOR-34541
CDC25Bdephosphorylation
→
up-regulates activity 		CDK1SIGNOR-276969
CDC25Bdephosphorylation
→
up-regulates activity 		CDK1SIGNOR-276970
CDC25Bdephosphorylation
→
up-regulates activity 		CDK2SIGNOR-277140
CDC25Bdephosphorylation
→
up-regulates 		CyclinB/CDK1SIGNOR-217511