| Name | CDC25B |
| ID | P30305 |
| Role | substrate |
| Enzymatic Domains |
Rhodanese 431-538 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | CDC25B | Ser230 | AFAQRPSsAPDLMCL | phosphorylation down-regulates activity | 17003105 | SIGNOR-149898 |
| RPS6K | CDC25B | Thr355 | NKRRRSVtPPEEQQE | phosphorylation up-regulates | 23708659 | SIGNOR-252779 |
| ROBO | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation down-regulates | 15150265 | SIGNOR-124843 |
| p38 | CDC25B | Ser375 | ARVLRSKsLCHDEIE | phosphorylation down-regulates activity | 11333986 | SIGNOR-107416 |
| BRSK1 | CDC25B | Ser375 | ARVLRSKsLCHDEIE | phosphorylation down-regulates | 15150265 | SIGNOR-124839 |
| MELK | CDC25B | Ser169 | VLRNITNsQAPDGRR | phosphorylation up-regulates | 15908796 | SIGNOR-137378 |
| p38 | CDC25B | Ser103 | ESSLSSEsSESSDAG | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276349 |
| CDK1 | CDC25B | Ser321 | KCQRLFRsPSMPCSV | phosphorylation up-regulates | 20801879 | SIGNOR-167641 |
| p38 | CDC25B | Ser101 | ASESSLSsESSESSD | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276350 |
| CDK1 | CDC25B | Ser160 | PVRLLGHsPVLRNIT | phosphorylation up-regulates | 12107172 | SIGNOR-90451 |
| RPS6K | CDC25B | Ser353 | VQNKRRRsVTPPEEQ | phosphorylation up-regulates | 23708659 | SIGNOR-252781 |
| CDC14A | CDC25B | – | dephosphorylation down-regulates activity | 20956543 | SIGNOR-276968 | |
| PRKACA | CDC25B | Ser321 | KCQRLFRsPSMPCSV | phosphorylation up-regulates activity | 27038604 | SIGNOR-280077 |
| AURKA | CDC25B | Ser353 | VQNKRRRsVTPPEEQ | phosphorylation up-regulates | 16082213 | SIGNOR-139396 |
| CyclinB/CDK1 | CDC25B | Ser160 | PVRLLGHsPVLRNIT | phosphorylation up-regulates | 12107172 | SIGNOR-216753 |
| RPS6KA1 | CDC25B | Ser353 | VQNKRRRsVTPPEEQ | phosphorylation up-regulates | 23708659 | SIGNOR-202121 |
| PCSK7 | CDC25B | – | phosphorylation down-regulates | 11333986 | SIGNOR-107423 | |
| MAPK8 | CDC25B | Ser103 | ESSLSSEsSESSDAG | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276351 |
| CSNK2A1 | CDC25B | Ser187 | AGSGAASsSGEDKEN | phosphorylation up-regulates activity | 12527891 | SIGNOR-250837 |
| BRSK1 | CDC25B | Ser375 | ARVLRSKsLCHDEIE | phosphorylation down-regulates activity | 15150265 | SIGNOR-107404 |
| MARK3 | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation up-regulates activity | 35017636 | SIGNOR-279223 |
| MARK3 | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation down-regulates activity | 35017636 | SIGNOR-279224 |
| CSNK2A1 | CDC25B | Ser186 | EAGSGAAsSSGEDKE | phosphorylation up-regulates activity | 12527891 | SIGNOR-250836 |
| MAPK8 | CDC25B | Ser101 | ASESSLSsESSESSD | phosphorylation down-regulates quantity by destabilization | 21807946 | SIGNOR-276352 |
| p38 | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation down-regulates activity | 11333986 | SIGNOR-107412 |
| PLK1 | CDC25B | – | phosphorylation up-regulates activity | 21640712 | SIGNOR-267560 | |
| RPS6KA1 | CDC25B | Thr355 | NKRRRSVtPPEEQQE | phosphorylation up-regulates | 23708659 | SIGNOR-202125 |
| MELK | CDC25B | Ser219 | HALAEWAsRREAFAQ | phosphorylation down-regulates activity | 12400006 | SIGNOR-255655 |
| ROBO | CDC25B | Ser375 | ARVLRSKsLCHDEIE | phosphorylation down-regulates | 15150265 | SIGNOR-124847 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | CDC25B PSer230 | phosphorylation down-regulates ⊣ | CDC25B | 17003105 | SIGNOR-149898 |
| RPS6K | phosphorylation up-regulates → | CDC25B PThr355 | phosphorylation up-regulates → | CDC25B | 23708659 | SIGNOR-252779 |
| ROBO | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation down-regulates ⊣ | CDC25B | 15150265 | SIGNOR-124843 |
| p38 | phosphorylation up-regulates → | CDC25B PSer375 | phosphorylation down-regulates ⊣ | CDC25B | 11333986 | SIGNOR-107416 |
| BRSK1 | phosphorylation up-regulates → | CDC25B PSer375 | phosphorylation down-regulates ⊣ | CDC25B | 15150265 | SIGNOR-124839 |
| MELK | phosphorylation up-regulates → | CDC25B PSer169 | phosphorylation up-regulates → | CDC25B | 15908796 | SIGNOR-137378 |
| p38 | phosphorylation up-regulates → | CDC25B PSer103 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276349 |
| CDK1 | phosphorylation up-regulates → | CDC25B PSer321 | phosphorylation up-regulates → | CDC25B | 20801879 | SIGNOR-167641 |
| p38 | phosphorylation up-regulates → | CDC25B PSer101 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276350 |
| CDK1 | phosphorylation up-regulates → | CDC25B PSer160 | phosphorylation up-regulates → | CDC25B | 12107172 | SIGNOR-90451 |
| RPS6K | phosphorylation up-regulates → | CDC25B PSer353 | phosphorylation up-regulates → | CDC25B | 23708659 | SIGNOR-252781 |
| PRKACA | phosphorylation up-regulates → | CDC25B PSer321 | phosphorylation up-regulates → | CDC25B | 27038604 | SIGNOR-280077 |
| AURKA | phosphorylation up-regulates → | CDC25B PSer353 | phosphorylation up-regulates → | CDC25B | 16082213 | SIGNOR-139396 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25B PSer160 | phosphorylation up-regulates → | CDC25B | 12107172 | SIGNOR-216753 |
| RPS6KA1 | phosphorylation up-regulates → | CDC25B PSer353 | phosphorylation up-regulates → | CDC25B | 23708659 | SIGNOR-202121 |
| MAPK8 | phosphorylation up-regulates → | CDC25B PSer103 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276351 |
| CSNK2A1 | phosphorylation up-regulates → | CDC25B PSer187 | phosphorylation up-regulates → | CDC25B | 12527891 | SIGNOR-250837 |
| BRSK1 | phosphorylation up-regulates → | CDC25B PSer375 | phosphorylation down-regulates ⊣ | CDC25B | 15150265 | SIGNOR-107404 |
| MARK3 | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation up-regulates → | CDC25B | 35017636 | SIGNOR-279223 |
| MARK3 | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation down-regulates ⊣ | CDC25B | 35017636 | SIGNOR-279224 |
| CSNK2A1 | phosphorylation up-regulates → | CDC25B PSer186 | phosphorylation up-regulates → | CDC25B | 12527891 | SIGNOR-250836 |
| MAPK8 | phosphorylation up-regulates → | CDC25B PSer101 | phosphorylation down-regulates ⊣ | CDC25B | 21807946 | SIGNOR-276352 |
| p38 | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation down-regulates ⊣ | CDC25B | 11333986 | SIGNOR-107412 |
| RPS6KA1 | phosphorylation up-regulates → | CDC25B PThr355 | phosphorylation up-regulates → | CDC25B | 23708659 | SIGNOR-202125 |
| MELK | phosphorylation up-regulates → | CDC25B PSer219 | phosphorylation down-regulates ⊣ | CDC25B | 12400006 | SIGNOR-255655 |
| ROBO | phosphorylation up-regulates → | CDC25B PSer375 | phosphorylation down-regulates ⊣ | CDC25B | 15150265 | SIGNOR-124847 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-149898 |
| RPS6K | phosphorylation → up-regulates | CDC25B | SIGNOR-252779 |
| ROBO | phosphorylation down-regulates | CDC25B | SIGNOR-124843 |
| p38 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-107416 |
| BRSK1 | phosphorylation down-regulates | CDC25B | SIGNOR-124839 |
| MELK | phosphorylation → up-regulates | CDC25B | SIGNOR-137378 |
| p38 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276349 |
| CDK1 | phosphorylation → up-regulates | CDC25B | SIGNOR-167641 |
| p38 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276350 |
| CDK1 | phosphorylation → up-regulates | CDC25B | SIGNOR-90451 |
| RPS6K | phosphorylation → up-regulates | CDC25B | SIGNOR-252781 |
| CDC14A | dephosphorylation → down-regulates activity | CDC25B | SIGNOR-276968 |
| PRKACA | phosphorylation → up-regulates activity | CDC25B | SIGNOR-280077 |
| AURKA | phosphorylation → up-regulates | CDC25B | SIGNOR-139396 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25B | SIGNOR-216753 |
| RPS6KA1 | phosphorylation → up-regulates | CDC25B | SIGNOR-202121 |
| PCSK7 | phosphorylation down-regulates | CDC25B | SIGNOR-107423 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276351 |
| CSNK2A1 | phosphorylation → up-regulates activity | CDC25B | SIGNOR-250837 |
| BRSK1 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-107404 |
| MARK3 | phosphorylation → up-regulates activity | CDC25B | SIGNOR-279223 |
| MARK3 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-279224 |
| CSNK2A1 | phosphorylation → up-regulates activity | CDC25B | SIGNOR-250836 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | CDC25B | SIGNOR-276352 |
| p38 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-107412 |
| PLK1 | phosphorylation → up-regulates activity | CDC25B | SIGNOR-267560 |
| RPS6KA1 | phosphorylation → up-regulates | CDC25B | SIGNOR-202125 |
| MELK | phosphorylation → down-regulates activity | CDC25B | SIGNOR-255655 |
| ROBO | phosphorylation down-regulates | CDC25B | SIGNOR-124847 |