| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MELK | CDC25B | Ser219 | HALAEWAsRREAFAQ | phosphorylation down-regulates activity | 12400006 | SIGNOR-255655 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MELK | phosphorylation up-regulates → | CDC25B PSer219 | phosphorylation down-regulates ⊣ | CDC25B | 12400006 | SIGNOR-255655 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MELK | phosphorylation → down-regulates activity | CDC25B | SIGNOR-255655 |