| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK3 | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation up-regulates activity | 35017636 | SIGNOR-279223 |
| MARK3 | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation down-regulates activity | 35017636 | SIGNOR-279224 |
| p38 | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation down-regulates activity | 11333986 | SIGNOR-107412 |
| ROBO | CDC25B | Ser323 | QRLFRSPsMPCSVIR | phosphorylation down-regulates | 15150265 | SIGNOR-124843 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK3 | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation up-regulates → | CDC25B | 35017636 | SIGNOR-279223 |
| MARK3 | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation down-regulates ⊣ | CDC25B | 35017636 | SIGNOR-279224 |
| p38 | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation down-regulates ⊣ | CDC25B | 11333986 | SIGNOR-107412 |
| ROBO | phosphorylation up-regulates → | CDC25B PSer323 | phosphorylation down-regulates ⊣ | CDC25B | 15150265 | SIGNOR-124843 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MARK3 | phosphorylation → up-regulates activity | CDC25B | SIGNOR-279223 |
| MARK3 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-279224 |
| p38 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-107412 |
| ROBO | phosphorylation down-regulates | CDC25B | SIGNOR-124843 |
